Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930363 | 0.88 | POLB (0.50) | HCAR2POLBTDP1MEN1KMT2A | |
| SCHEMBL28334041 | 0.88 | POLB (0.50) | HCAR2POLBTDP1MEN1KMT2A | |
| SCHEMBL89539 | 0.88 | POLB (0.50) | HCAR2POLBTDP1MEN1KMT2A | |
| SCHEMBL11741292 | 0.86 | POLB (0.49) | HCAR2POLBTDP1MEN1KMT2A | |
| P-Xylene SCHEMBL28193363 | 0.81 | P4HTM (0.49) | HCAR2POLBTDP1MEN1KMT2A | |
| SCHEMBL27815495 | 0.81 | POLB (0.45) | HCAR2POLBTDP1MEN1KMT2A | |
| O-Xylene SCHEMBL28193365 | 0.78 | MEN1 (0.53) | POLBTDP1MEN1KMT2ANPC1 | |
| SCHEMBL2031774 | 0.78 | POLB (0.42) | HCAR2POLBTDP1MEN1KMT2A | |
| Pyrazinoic Acid SCHEMBL22119726 | 0.76 | KDM4E (0.71) | HCAR2POLBTDP1MEN1KMT2A | |
| Benzoic Acid SCHEMBL28285935 | 0.76 | MEN1 (0.51) | POLBTDP1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108017586-A | A kind of preparation method of 5-Methylpyrazine-2-carboxylic acid | 常州工程职业技术学院 | 2018-05-11 | — | — | CN | disclosed |