Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26184965 | 0.88 | MAPT (0.38) | SMN1; SMN2MAPTTSHRALDH1A1NPC1 | |
| SCHEMBL17165414 | 0.86 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTTSHRALDH1A1HTT | |
| SCHEMBL891238 | 0.84 | GPR55 (0.41) | SMN1; SMN2MAPTTSHRALDH1A1HSD17B10 | |
| SCHEMBL28320847 | 0.78 | ADORA3 (0.43) | SMN1; SMN2MAPTTSHRALDH1A1NPC1 | |
| SCHEMBL28264477 | 0.78 | ESR1 (0.42) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL28869311 | 0.78 | XDH (0.33) | SMN1; SMN2MAPTTSHRALDH1A1NPC1 | |
| SCHEMBL28216640 | 0.78 | HTR1A (0.41) | SMN1; SMN2NPC1RAB9ADYRK1AMAPK14 | |
| SCHEMBL24449037 | 0.76 | IKBKE (0.48) | SMN1; SMN2MAPTALDH1A1HTTNPC1 | |
| SCHEMBL21295662 | 0.75 | DYRK1A (0.41) | SMN1; SMN2MAPTTSHRALDH1A1HTT | |
| SCHEMBL21879687 | 0.74 | IMPDH2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108440515-A | Substituted benzofuranyl and benzoxazole based compound and application thereof | 卡尔约药物治疗公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-105492437-B | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | 卡尔约药物治疗公司 | 2018-05-11 | — | — | CN | disclosed |