Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Benzofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.39 |
| ▸ | HTR1B known ✓ | P28222 | 2/20 | 0.38 |
| ▸ | MCL1 known ✓ | Q07820 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 6/20 | 0.41 |
| ▸ | CA12 | O43570 | 5/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.39 |
| ▸ | WNT3A | P56704 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | EPM2A | O95278 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
| ▸ | CDC14A | Q9UNH5 | 1/20 | 0.37 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzofuran SCHEMBL8100958 | 0.92 | MAOA (0.42) | CA2CA12MAOAMAOBFTO | |
| Benzofuran SCHEMBL27823689 | 0.88 | MAOA (0.44) | CA2CA12MAOAMAOBFTO | |
| Benzofuran SCHEMBL11148189 | 0.88 | CA2 (0.43) | CA2CA12MAOAMAOBFTO | |
| Benzofuran SCHEMBL28153539 | 0.85 | MAOA (0.41) | CA2CA12MAOAMAOBFTO | |
| Benzofuran SCHEMBL27497715 | 0.85 | CYP2A6 (0.42) | CA2CA12MAOAMAOBFTO | |
| Benzofuran SCHEMBL28870582 | 0.83 | CTNNB1 (0.45) | CA2CA12MAOAMAOBFTO | |
| Benzofuran SCHEMBL2913948 | 0.83 | MAOA (0.47) | CA2CA12MAOAMAOBFTO | |
| Benzofuran SCHEMBL142133 | 0.83 | EPM2A (0.44) | CA2CA12MAOAMAOBFTO | |
| Benzofuran SCHEMBL27823690 | 0.83 | MAOA (0.40) | CA2CA12MAOAMAOBFTO | |
| Benzofuran SCHEMBL28603096 | 0.83 | HTR1B (0.41) | CA2CA12MAOAMAOBFTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107935972-A | 5 [2 hydroxyl 3 (isopropylamine base) propoxyl group] benzofuran derivatives and its application | 沈阳药科大学 | 2018-04-20 | — | — | CN | claimed |
| CN-114144224-B | Drug composition delivery devices and methods | 保科特纳洛克斯恩公司 | 2024-08-09 | — | — | CN | disclosed |
| CN-117941689-A | Weeding composition containing sethoxydim and ethofumesate and application thereof | 河北省农林科学院粮油作物研究所 | 2024-04-30 | — | — | CN | disclosed |
| CN-114144224-A | Drug composition delivery device and method | 保科特纳洛克斯恩公司 | 2022-03-04 | — | — | CN | disclosed |