SCHEMBL2822012

SCHEMBL2822012

CC[Si](C#Cc1ccc(O)cc1)(CC)CC

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 6/20 0.44
ESR1 P03372 5/20 0.43
CA12 O43570 2/20 0.38
CA2 P00918 2/20 0.38
CA3 P07451 2/20 0.38
CA9 Q16790 2/20 0.38
CA14 Q9ULX7 2/20 0.38
CA6 P23280 1/20 0.38
LMNA P02545 3/20 0.35
CYP3A4 P08684 3/20 0.35
MAPT P10636 3/20 0.35
ALOX15 P16050 3/20 0.35
CYP1A2 P05177 2/20 0.35
PGR P06401 2/20 0.35
CHRM2 P08172 2/20 0.35
ADORA3 P0DMS8 2/20 0.35
AR P10275 2/20 0.35
CYP2D6 P10635 2/20 0.35
CHRM1 P11229 2/20 0.35
CYP2C9 P11712 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2185739 0.79 GRM5 (0.40) APPLMNACYP1A2CYP2D6CYP2C19
SCHEMBL3573293 0.78 APP (0.48) APPLMNACYP3A4MAPTALOX15
SCHEMBL1230907 0.76 APP (0.48) APPESR1CA12CA2CA3
SCHEMBL5687827 0.75 P2RY6 (0.32) P2RY6
SCHEMBL16924578 0.75 ALDH1A1 (0.41) LMNAMAPTMEN1ALDH1A1KMT2A
SCHEMBL15062769 0.73 PTPN11 (0.50) CA12CA2CA9CA14MAPT
SCHEMBL7033211 0.71 APP (0.48) APPESR1CA12CA2CA3
SCHEMBL14400750 0.71 APP (0.74) APPESR1CA12CA2CA3
SCHEMBL673609 0.71 APP (0.74) APPESR1CA12CA2CA3
SCHEMBL30283030 0.71 APP (0.44) APPESR1CA12CA2CA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100304381-A1 FLUORESCENT NUCLEOBASE CONJUGATES HAVING ANIONIC LINKERS Life Technologies Corporation (US) 2010-12-02 US disclosed
US-7687236-B2 Fluorescent nucleobase conjugates having anionic linkers APPLIED BIOSYSTEMS, LLC (US) 2010-03-30 US disclosed
EP-1317464-B1 FLUORESCENT NUCLEOBASE CONJUGATES HAVING ANIONIC LINKERS APPLERA CORP (US) 2009-05-13 EP disclosed
US-20090092986-A1 Fluorescent Nucleobase Conjugates Having Anionic Linkers APPLIED BIOSYSTEMS INC. (US) 2009-04-09 US disclosed
US-7429651-B2 Fluorescent nucleobase conjugates having anionic linkers APPLERA CORPORATION (US) 2008-09-30 US disclosed
US-20050250119-A1 Fluorescent nucleobase conjugates having anionic linkers APPLERA CORPORATION (US) 2005-11-10 US disclosed
US-6811979-B2 NUCLEOTIDE DERIVATIVE FOR USE IN SEQUENCE DETERMINATION OF NUCLEIC ACID MOLECULE APPLERA CORPORATION 2004-11-02 US disclosed
EP-1317464-A2 FLUORESCENT NUCLEOBASE CONJUGATES HAVING ANIONIC LINKERS Applera Corporation (US) 2003-06-11 EP disclosed
US-20020102590-A1 Fluorescent nucleobase conjugates having anionic linkers PE CORPORATION (NY) (US) 2002-08-01 US disclosed
WO-2002030944-A2 FLUORESCENT NUCLEOBASE CONJUGATES HAVING ANIONIC LINKERS APPLERA CORPORATION (US) 2002-04-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050250119-A1 Fluorescent nucleobase conjugates having anionic linkers DNTT, DUT, NT5C3B APP 4729/4885ESR1 1781/4885CA12 3307/4885
US-20100304381-A1 FLUORESCENT NUCLEOBASE CONJUGATES HAVING ANIONIC LINKERS DNTT, DUT, NT5C3B APP 4729/4885ESR1 1781/4885CA12 3307/4885
US-20020102590-A1 Fluorescent nucleobase conjugates having anionic linkers DNTT, DUT, NT5C3B APP 4729/4885ESR1 1781/4885CA12 3307/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.