Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2822191 | 0.86 | GRM5 (0.43) | GRM5PPARGPPARDPPARATP53 | |
| SCHEMBL2827433 | 0.85 | PPARG (0.38) | GRM5PPARGPPARDPPARAHSD17B10 | |
| SCHEMBL2821758 | 0.82 | ERN1 (0.44) | GRM5FFAR1 | |
| SCHEMBL11758794 | 0.79 | TP53 (0.45) | TP53MAPTMAOAMAOBMEN1 | |
| SCHEMBL2822186 | 0.76 | PPARD (0.43) | GRM5PPARGPPARDPPARAALDH1A1 | |
| SCHEMBL2822348 | 0.76 | PPARD (0.41) | GRM5PPARDMEN1KMT2AALDH1A1 | |
| SCHEMBL2069381 | 0.76 | PPARA (0.46) | PPARGPPARDPPARAFFAR1 | |
| SCHEMBL2825493 | 0.73 | HSP90AA1 (0.34) | GRM5PPARGPPARDPPARAMEN1 | |
| SCHEMBL2827431 | 0.72 | PPARG (0.40) | GRM5PPARGPPARDPPARAFFAR1 | |
| SCHEMBL51244 | 0.72 | TP53 (0.54) | TP53MAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745003-B1 | NOVEL COMPOUNDS, THEIR PREPARATION AND USE | HIGH POINT PHARMACEUTICALS LLC (US) | 2010-10-27 | — | — | EP | claimed |