Improsulfan

Improsulfan

SCHEMBL28223296

C1CN1.CS(=O)(=O)OCCCNCCCOS(C)(=O)=O

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.54
USP2 O75604 1/20 0.54
ALDH1A1 P00352 1/20 0.54
LMNA P02545 1/20 0.54
MMP9 P14780 1/20 0.54
ALOX15 P16050 1/20 0.54
TSHR P16473 1/20 0.54
SAT1 P21673 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Improsulfan SCHEMBL8954 0.89 USP2 (0.67) KDM4EUSP2ALDH1A1LMNAMMP9
Improsulfan SCHEMBL844581 0.87 USP2 (0.64) KDM4EUSP2ALDH1A1LMNAMMP9
SCHEMBL27700119 0.87 TSHR (0.64) KDM4EUSP2ALDH1A1LMNAMMP9
Improsulfan SCHEMBL10628525 0.87 USP2 (0.64) KDM4EUSP2ALDH1A1LMNAMMP9
Improsulfan SCHEMBL5886799 0.87 TSHR (0.71) KDM4EUSP2ALDH1A1LMNAMMP9
Improsulfan SCHEMBL27654142 0.85 TSHR (0.61) KDM4EUSP2ALDH1A1LMNAMMP9
Busulfan SCHEMBL28144825 0.85 TSHR (0.75) KDM4EUSP2ALDH1A1LMNAMMP9
Improsulfan SCHEMBL6228502 0.82 KDM4E (0.56) KDM4EUSP2ALDH1A1LMNAMMP9
SCHEMBL5551062 0.78 ALOX15 (0.52) KDM4EUSP2ALDH1A1LMNAMMP9
SCHEMBL14608855 0.78 ALDH1A1 (0.52) KDM4EUSP2ALDH1A1LMNAMMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108137706-A Drug-conjugated bispecific antigen-binding constructs 酵活有限公司 2018-06-08 CN disclosed