Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.71 |
| ▸ | USP2 | O75604 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | MMP9 | P14780 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | CA1 | P00915 | 16/20 | 0.39 |
| ▸ | CA2 | P00918 | 16/20 | 0.39 |
| ▸ | CA9 | Q16790 | 15/20 | 0.39 |
| ▸ | CA12 | O43570 | 5/20 | 0.37 |
| ▸ | CA7 | P43166 | 5/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.37 |
| ▸ | CA3 | P07451 | 4/20 | 0.37 |
| ▸ | CA4 | P22748 | 4/20 | 0.37 |
| ▸ | CA6 | P23280 | 4/20 | 0.37 |
| ▸ | CA5A | P35218 | 4/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Improsulfan SCHEMBL8954 | 0.98 | USP2 (0.67) | TSHRUSP2KDM4EALDH1A1LMNA | |
| Improsulfan SCHEMBL10628525 | 0.95 | USP2 (0.64) | TSHRUSP2KDM4EALDH1A1LMNA | |
| SCHEMBL27700119 | 0.95 | TSHR (0.64) | TSHRUSP2KDM4EALDH1A1LMNA | |
| Improsulfan SCHEMBL844581 | 0.95 | USP2 (0.64) | TSHRUSP2KDM4EALDH1A1LMNA | |
| Improsulfan SCHEMBL27654142 | 0.93 | TSHR (0.61) | TSHRUSP2KDM4EALDH1A1LMNA | |
| Improsulfan SCHEMBL6228502 | 0.89 | KDM4E (0.56) | TSHRUSP2KDM4EALDH1A1LMNA | |
| Improsulfan SCHEMBL28223296 | 0.87 | KDM4E (0.54) | TSHRUSP2KDM4EALDH1A1LMNA | |
| SCHEMBL14608855 | 0.86 | ALDH1A1 (0.52) | TSHRUSP2KDM4EALDH1A1LMNA | |
| SCHEMBL5551062 | 0.86 | ALOX15 (0.52) | TSHRUSP2KDM4EALDH1A1LMNA | |
| Busulfan SCHEMBL4764696 | 0.84 | TSHR (1.00) | TSHRUSP2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7019002-B2 | Substituted on 8th position with benzoic acid, ester or amide groups; anticancer agents | PHARMACIA & UPJOHN, S.P.A. (IT) | 2006-03-28 | — | — | US | disclosed |
| EP-1390368-B1 | DISUBSTITUTED 7,9-GUANINIUM HALIDES AS TELOMERASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-10-26 | — | — | EP | disclosed |
| US-20050037990-A1 | Disubstituted 7,9-guanines halides as telomerase inhibitors | PHARMACIA ITALIA (IT) | 2005-02-17 | — | — | US | disclosed |
| US-20040138212-A1 | Disubstituted 1,7-guanines | PHARMACIA ITALIA, S.P.A. (IT) | 2004-07-15 | — | — | US | disclosed |
| US-20040132807-A1 | Aurones as telomerase inhibitors | PHARMACIA ITALIA SPA (IT) | 2004-07-08 | — | — | US | disclosed |
| US-20040063665-A1 | Substituted benzopyranones as telomerase inhibitors | PHARMACIA ITALIA S.P.A. (IT) | 2004-04-01 | — | — | US | disclosed |
| EP-1390368-A1 | DISUBSTITUTED 7,9-GUANINIUM HALIDES AS TELOMERASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-02-25 | — | — | EP | disclosed |
| EP-1383766-A1 | DISUBSTITUTED 1,7-GUANINES | Pharmacia Italia S.p.A. (IT) | 2004-01-28 | — | — | EP | disclosed |
| EP-1381359-A1 | AURONES AS TELOMERASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-01-21 | — | — | EP | disclosed |
| US-20040009993-A1 | Pyridopyrimidinones derivatives as telomerase inhibitors | PHARMACIA ITALIA S.P.A. | 2004-01-15 | — | — | US | disclosed |
| EP-1373244-A2 | SUBSTITUTED BENZOPYRANONES AS TELOMERASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-01-02 | — | — | EP | disclosed |
| US-20030186978-A1 | Novel telomerase inhibitors | PHARMACIA ITALIA, SPA (IT) | 2003-10-02 | — | — | US | disclosed |
| WO-2002090358-A1 | DISUBSTITUTED 7,9-GUANINIUM HALIDES AS TELOMERASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2002-11-14 | — | — | WO | disclosed |
| WO-2002090357-A1 | DISUBSTITUTED 1,7-GUANINES | PHARMACIA ITALIA S.P.A. (IT) | 2002-11-14 | — | — | WO | disclosed |
| US-20020160983-A1 | Substituted benzopyranones as telomerase inhibitors | PHARMACIA ITALIA S.P.A. (IT) | 2002-10-31 | — | — | US | disclosed |
| WO-2002083123-A1 | AURONES AS TELOMERASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-10-24 | — | — | WO | disclosed |
| WO-2002074036-A2 | SUBSTITUTED BENZOPYRANONES AS TELOMERASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-09-26 | — | — | WO | disclosed |
| WO-2001096339-A1 | NOVEL TELOMERASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138212-A1 | Disubstituted 1,7-guanines | GDA, UNG, TYMS | TSHR 4457/4885USP2 2878/4885KDM4E 1444/4885 |
| US-20040132807-A1 | Aurones as telomerase inhibitors | TERT, TERF2, TERF2IP | TSHR 3411/4885USP2 2117/4885KDM4E 818/4885 |
| US-20020160983-A1 | Substituted benzopyranones as telomerase inhibitors | TERT, TERF2, TERF2IP | TSHR 3660/4885USP2 2359/4885KDM4E 908/4885 |
| US-20040009993-A1 | Pyridopyrimidinones derivatives as telomerase inhibitors | TERT, TERF2, TERF2IP | TSHR 3292/4885USP2 3140/4885KDM4E 840/4885 |
| US-20030186978-A1 | Novel telomerase inhibitors | TERT, TERF2IP, TERF2 | TSHR 2517/4885USP2 1638/4885KDM4E 1491/4885 |
| US-20050037990-A1 | Disubstituted 7,9-guanines halides as telomerase inhibitors | TERT, POT1, RNMT | TSHR 2693/4885USP2 3013/4885KDM4E 637/4885 |
| US-20040063665-A1 | Substituted benzopyranones as telomerase inhibitors | TERT, TERF2, TERF2IP | TSHR 3682/4885USP2 2374/4885KDM4E 889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.