Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL23493543 | 1.00 | CA5A (0.42) | CA5ACA5BALDH1A1TDP1KDM4E | |
| SCHEMBL603996 | 0.95 | ALDH1A1 (0.41) | CA5ACA5BALDH1A1TDP1KDM4E | |
| SCHEMBL10337158 | 0.92 | ALDH1A1 (0.39) | CA5ACA5BALDH1A1TDP1KDM4E | |
| SCHEMBL10337286 | 0.84 | ALDH1A1 (0.38) | ALDH1A1TDP1KDM4EPOLBGAA | |
| SCHEMBL2349341 | 0.83 | ALDH1A1 (0.33) | ALDH1A1TDP1KDM4E | |
| Nitric Acid SCHEMBL28027279 | 0.81 | — | — | |
| Trolamine SCHEMBL2396169 | 0.78 | CA5A (0.47) | CA5ACA5BALDH1A1TDP1KDM4E | |
| Trolamine SCHEMBL725388 | 0.78 | CA5A (0.47) | CA5ACA5BALDH1A1TDP1KDM4E | |
| SCHEMBL11653734 | 0.77 | LMNA (0.33) | ALDH1A1TDP1KDM4E | |
| Trolamine SCHEMBL9299420 | 0.76 | CA5A (0.44) | CA5ACA5BALDH1A1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107422014-B | Modified electrode and preparation method and detection method for detection of alkaline phosphatase | 云南大学 | 2019-07-12 | — | — | CN | disclosed |
| CN-108375616-A | A kind of liquid crystal biosensor of detection of alkaline phosphatase and its preparation method and application | 云南大学 | 2018-08-07 | — | — | CN | disclosed |