Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2823282 | 0.89 | ENPP1 (0.39) | PTGDR2 | |
| SCHEMBL2825609 | 0.87 | SMN1; SMN2 (0.44) | NR1H2NR1H3 | |
| SCHEMBL2824252 | 0.87 | FABP3 (0.38) | NR1H2PTGDR2 | |
| SCHEMBL2826082 | 0.86 | ENPP1 (0.43) | — | |
| SCHEMBL2825660 | 0.85 | NR1H2 (0.41) | NR1H2NR1H3PTGS2 | |
| SCHEMBL2827841 | 0.85 | NR1H2 (0.41) | NR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL2824206 | 0.83 | DHODH (0.37) | NR1H2PTGDR2NR1H3 | |
| SCHEMBL2821965 | 0.81 | FABP3 (0.39) | PTGDR2 | |
| SCHEMBL2826114 | 0.80 | CYP1A2 (0.39) | NR1H2PTGS2PTGS1 | |
| SCHEMBL2829017 | 0.80 | PTGS2 (0.43) | NR1H2PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |