Known targets — ChEMBL curated mechanism
POLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PRIM1PRIM2
The experimentally established mechanism targets of Cytidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | MTOR | P42345 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.65 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.65 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.65 |
| ▸ | PNP | P00491 | 1/20 | 0.48 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | HBB | P68871 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12959076 | 0.91 | PNP (0.56) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL40998 | 0.91 | PNP (0.56) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL12820927 | 0.91 | PNP (0.56) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL30326363 | 0.90 | PNP (0.55) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL30867121 | 0.83 | PNP (0.47) | PNPCYP3A4MAPTTLR7MEN1 | |
| SCHEMBL19552748 | 0.82 | PNP (0.48) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL19183038 | 0.82 | PNP (0.45) | PNPTLR7MEN1KMT2A | |
| Triphosphate SCHEMBL31158164 | 0.82 | PNP (0.47) | LMNAPNPBLMPMP22TLR7 | |
| Guanosine SCHEMBL536141 | 0.81 | LMNA (0.69) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL29565496 | 0.81 | PNP (0.45) | PNPCYP3A4MAPTTLR7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108430456-A | Cancer vaccine | 摩登纳特斯有限公司 | 2018-08-21 | — | — | CN | disclosed |