Known targets — ChEMBL curated mechanism
POLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PRIM1PRIM2
The experimentally established mechanism targets of Guanosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | MTOR | P42345 | 2/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.69 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.69 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.69 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | GSK3A | P49840 | 2/20 | 0.59 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.59 |
| ▸ | PNP | P00491 | 2/20 | 0.59 |
| ▸ | HINT1 | P49773 | 4/20 | 0.58 |
| ▸ | NT5E | P21589 | 2/20 | 0.58 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanosine SCHEMBL1983917 | 0.96 | LMNA (0.64) | LMNAMTORTHRBMDM2NCOA1 | |
| Guanosine SCHEMBL27546322 | 0.93 | ADORA3 (0.63) | LMNAMTORTHRBMDM2NCOA1 | |
| Cytarabine 5'-Phosphate SCHEMBL28224063 | 0.91 | NT5E (0.67) | LMNAMTORTHRBMDM2NCOA1 | |
| E626 SCHEMBL8655976 | 0.91 | NT5E (0.67) | LMNAMTORTHRBMDM2NCOA1 | |
| Cytarabine 5'-Phosphate SCHEMBL249411 | 0.91 | NT5E (0.67) | LMNAMTORTHRBMDM2NCOA1 | |
| Guanosine SCHEMBL4879720 | 0.91 | P2RY2 (0.59) | LMNAMTORTHRBMDM2NCOA1 | |
| Cytidine SCHEMBL29175537 | 0.91 | NT5E (0.57) | LMNAMTORTHRBMDM2NCOA1 | |
| Guanosine SCHEMBL24049417 | 0.90 | HPGD (0.76) | LMNAHPGDGSK3ARPS6KA3MAPK14 | |
| Guanosine SCHEMBL24049608 | 0.90 | HPGD (0.76) | LMNAHPGDGSK3ARPS6KA3MAPK14 | |
| Guanosine SCHEMBL11986902 | 0.90 | HPGD (0.76) | LMNAHPGDGSK3ARPS6KA3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 194 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105263502-A | Pharmaceutical composition comprising GPG oligodeoxynucleotide and cyclic GMP | INTERVET INT BV | 2016-01-20 | — | — | CN | claimed |
| EP-4330384-A1 | ENZYME COMPOSITION WITH AT LEAST TWO DIFFERENT THERMOSTABLE POLYPEPTIDES HAVING TYPE II DNA METHYLTRANSFERASE ACTIVITY | Blucon Biotech GmbH (DE) | 2024-03-06 | — | — | EP | disclosed |
| CN-117441014-A | Enzyme composition having at least two different thermostable polypeptides having type II DNA methyltransferase activity | 布鲁克生物科技公司 | 2024-01-23 | — | — | CN | disclosed |
| US-20230330219-A1 | NUCLEIC ACID NANOSTRUCTURE PLATFORM FOR PROGRAMMING IMMUNE STIMULATION | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2023-10-19 | — | — | US | disclosed |
| US-20230034423-A1 | METHODS OF MULTI-SPECIES INSECT PEST CONTROL | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2023-02-02 | — | — | US | disclosed |
| US-11116221-B2 | Pest control methods | FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) | 2021-09-14 | — | — | US | disclosed |
| WO-2021099377-A1 | METHODS OF MULTI-SPECIES INSECT PEST CONTROL | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2021-05-27 | — | — | WO | disclosed |
| EP-3825408-A1 | METHODS OF MULTI-SPECIES INSECT PEST CONTROL | FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V. (DE) | 2021-05-26 | — | — | EP | disclosed |
| EP-2981609-B1 | NOVEL DNA-POLYMERASES | BIORON GMBH (DE) | 2020-04-29 | — | — | EP | disclosed |
| EP-3634431-A1 | THERAPEUTIC COMPOSITIONS AND METHODS FOR TREATING HEPATITIS B | Arbutus Biopharma Corporation (US) | 2020-04-15 | — | — | EP | disclosed |
| US-5925517-A | HYBRIDIZATION PROBE OF SINGLE-STRANDED SEQUENCE COMPLEMENTARY TO TARGET, FLANKED BY OLIGONUCLEOTIDE ARMS WITH INTERACTING LABELS CAPABLE OF FORMING STEM DUPLEX; HYBRIDIZATION WITH TARGET ALTERS LEVEL OF SIGNAL AT LEAST TEN PERCENT | THE PUBLIC HEALTH RESEARCH INSTITUTE OF THE CITY OF NEW YORK, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| EP-0728218-A4 | HYBRIDIZATION PROBES FOR NUCLEIC ACID DETECTION, UNIVERSAL STEMS, METHODS AND KITS | NEW YORK HEALTH RES INST (US) | 1998-06-17 | — | — | EP | disclosed |
| EP-0745690-A2 | Detectably labeled dual conformation oligonucleotide Probes, Assays and Kits | THE PUBLIC HEALTH RESEARCH INSTITUTE OF THE CITY OF NEW YORK, INC. (US) | 1996-12-04 | — | — | EP | disclosed |
| EP-0742838-A1 | METHODS FOR THE ELIMINATION OF DNA SEQUENCING ARTIFACTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-11-20 | — | — | EP | disclosed |
| EP-0728218-A1 | HYBRIDIZATION PROBES FOR NUCLEIC ACID DETECTION, UNIVERSAL STEMS, METHODS AND KITS | THE PUBLIC HEALTH RESEARCH INSTITUTE OF THE CITY OF NEW YORK, INC. (US) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995033839-A1 | RECOMBINANT LEUKOTRIENE-C4 SYNTHASE | G.D. SEARLE & CO. (US) | 1995-12-14 | — | — | WO | disclosed |
| WO-1995020682-A1 | METHODS FOR THE ELIMINATION OF DNA SEQUENCING ARTIFACTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-08-03 | — | — | WO | disclosed |
| WO-1995013399-A1 | HYBRIDIZATION PROBES FOR NUCLEIC ACID DETECTION, UNIVERSAL STEMS, METHODS AND KITS | THE PUBLIC HEALTH RESEARCH INSTITUTE OF THE CITY OF NEW YORK, INC. (US) | 1995-05-18 | — | — | WO | disclosed |
| US-4130641-A | Induction of interferon production by modified nucleic acid complexes | HEM RESEARCH, INC. | 1978-12-19 | — | — | US | disclosed |
| US-4024222-A | INDUCES INTERFERON PRODUCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 1977-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11116221-B2 | Pest control methods | PTPRG, PTPA, PTPRS | LMNA 4625/4885MTOR 967/4885THRB 2529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.