Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN1 | Q92952 | 1/20 | 0.62 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.62 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.62 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.61 |
| ▸ | SYK | P43405 | 13/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | PRKCA | P17252 | 1/20 | 0.49 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2819228 | 0.85 | CDK4 (0.54) | KCNN1KCNN2KCNN3SYKABL1 | |
| SCHEMBL4903188 | 0.84 | KARS1 (0.64) | KCNN1KCNN2KCNN3SLC2A1SYK | |
| Hydrochloric Acid SCHEMBL4904575 | 0.83 | KARS1 (0.62) | KCNN1KCNN2KCNN3SLC2A1SYK | |
| SCHEMBL7471678 | 0.82 | ABL1 (0.64) | SYKABL1BCRPRKCA | |
| SCHEMBL7464938 | 0.81 | KDR (0.64) | SYKABL1BCRPRKCAKDR | |
| SCHEMBL3951508 | 0.81 | KDR (0.50) | KCNN1KCNN2KCNN3SLC2A1SYK | |
| SCHEMBL7477243 | 0.81 | SYK (0.62) | SYKABL1BCRPRKCALCK | |
| SCHEMBL7469712 | 0.81 | SYK (0.49) | SYKABL1BCRPRKCANPC1 | |
| SCHEMBL2321728 | 0.78 | CDK4 (0.52) | KCNN1KCNN2KCNN3SYKABL1 | |
| SCHEMBL3137926 | 0.78 | KCNN1 (0.60) | KCNN1KCNN2KCNN3SLC2A1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742634-B1 | POLYCYCLIC PYRIMIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN INC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7560464-B2 | Polycyclic pyrimidines as potassium ion channel modulators | ICAGEN, INC. (US) | 2009-07-14 | — | — | US | disclosed |
| US-20050267089-A1 | Polycyclic pyrimidines as potassium ion channel modulators | ICAGEN, INC. (US) | 2005-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267089-A1 | Polycyclic pyrimidines as potassium ion channel modulators | KCNJ2, KCNJ1, KCNJ11 | KCNN1 10/4885KCNN2 9/4885KCNN3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.