Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477243 | 0.89 | SYK (0.62) | SYKSRCRETABL1BCR | |
| SCHEMBL7466250 | 0.82 | CAMKK2 (0.50) | SYKSRCABL1BCRPRKCA | |
| SCHEMBL17666287 | 0.81 | RAPGEF4 (0.55) | SMN1; SMN2MAPTHTTKMT2ANPSR1 | |
| SCHEMBL2823600 | 0.81 | KCNN1 (0.62) | SYKABL1BCRPRKCAGSK3B | |
| SCHEMBL7471678 | 0.80 | ABL1 (0.64) | SYKSRCRETABL1BCR | |
| SCHEMBL7472267 | 0.80 | PIK3CG (0.57) | SYKSRCABL1BCRPRKCA | |
| SCHEMBL4893292 | 0.79 | ABL1 (0.65) | SYKSRCRETABL1BCR | |
| SCHEMBL7464938 | 0.79 | KDR (0.64) | SYKSRCABL1BCRPRKCA | |
| SCHEMBL22628286 | 0.78 | ABL1 (0.70) | SRCABL1BCRPRKCA | |
| SCHEMBL7461176 | 0.77 | SYK (0.62) | SYKABL1BCRPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |