Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 4/20 | 0.49 |
| ▸ | BCR | P11274 | 4/20 | 0.49 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469712 | 0.89 | SYK (0.49) | SYKSRCABL1BCRPRKCA | |
| SCHEMBL4893292 | 0.87 | ABL1 (0.65) | SYKSRCABL1BCRCAMKK2 | |
| SCHEMBL7466250 | 0.85 | CAMKK2 (0.50) | SYKSRCABL1BCRCAMKK2 | |
| SCHEMBL22169828 | 0.83 | CAMKK2 (0.59) | SYKABL1BCRCAMKK2PRKCA | |
| SCHEMBL4901365 | 0.82 | CAMKK2 (0.67) | SYKABL1BCRCAMKK2PRKCA | |
| SCHEMBL4903403 | 0.82 | ABL1 (0.67) | SYKSRCABL1BCRCAMKK2 | |
| SCHEMBL28434538 | 0.82 | PRKCA (0.53) | SYKABL1BCRPRKCAPDGFRB | |
| SCHEMBL4903437 | 0.81 | PDGFRA (0.73) | ABL1BCRPRKCAPDGFRBPDGFRA | |
| SCHEMBL4902265 | 0.81 | ALDH1A1 (0.53) | SYKABL1BCRPRKCAPDGFRB | |
| SCHEMBL22169836 | 0.81 | ABCB1 (0.56) | SYKSRCABL1BCRCAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |