Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.62 |
| ▸ | FBP1 | P09467 | 2/20 | 0.60 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | VCP | P55072 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | SNCA | P37840 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8865995 | 0.84 | GLO1 (0.64) | NFE2L2MAPTMAOBFBP1GLO1 | |
| SCHEMBL8866005 | 0.84 | GLO1 (0.64) | NFE2L2MAPTMAOBFBP1GLO1 | |
| SCHEMBL11216772 | 0.83 | MAPT (0.62) | NFE2L2MAPTMAOBFBP1GLO1 | |
| SCHEMBL7828360 | 0.83 | MAPT (0.62) | NFE2L2MAPTMAOBFBP1GLO1 | |
| SCHEMBL7828363 | 0.83 | MAPT (0.62) | NFE2L2MAPTMAOBFBP1GLO1 | |
| SCHEMBL11222310 | 0.82 | FBP1 (0.62) | NFE2L2MAPTMAOBFBP1GLO1 | |
| SCHEMBL11222306 | 0.82 | FBP1 (0.62) | NFE2L2MAPTMAOBFBP1GLO1 | |
| SCHEMBL27942881 | 0.81 | BCHE (0.59) | MAOBFBP1MEN1KMT2ACES2 | |
| SCHEMBL2685238 | 0.80 | CES2 (0.61) | MAPTMAOBFBP1MEN1KMT2A | |
| SCHEMBL2685237 | 0.80 | CES2 (0.61) | MAPTMAOBFBP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108570004-A | A kind of compound that there is double action to 5-HT and its application in treating depression | 郝惠敏 | 2018-09-25 | — | — | CN | disclosed |
| CN-108484485-A | A kind of compound that there is double action to 5-HT and its application in treating depression | 郝惠敏 | 2018-09-04 | — | — | CN | disclosed |
| CN-108484544-A | A kind of compound that there is double action to 5-HT and its application in treating depression | 郝惠敏 | 2018-09-04 | — | — | CN | disclosed |