SCHEMBL28239209

SCHEMBL28239209

Nc1ncc(Cc2ccccc2)c(N)c1N

nearest known ligand 0.62

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 1/20 0.46
DHFR P00374 1/20 0.43
HTR2A P28223 1/20 0.42
CALM1 P0DP23 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9044787 0.87 AOC3 (0.42) AOC3DHFR
SCHEMBL16486606 0.83 AOC3 (0.42) AOC3HTR2A
SCHEMBL28238100 0.79 HTT (0.49)
SCHEMBL9042020 0.79 ROCK1 (0.42) AOC3DHFR
SCHEMBL7499087 0.78 LTA4H (0.43) AOC3HTR2ACALM1
SCHEMBL380792 0.77 DHFR (0.67) DHFR
Hydrochloric Acid SCHEMBL8377343 0.76 DHFR (0.65) DHFR
Water SCHEMBL28837029 0.76 DHFR (0.65) DHFR
SCHEMBL5727329 0.74 DHFR (0.49) DHFR
SCHEMBL5726544 0.74 DHFR (0.49) DHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108498504-A A kind of pharmaceutical composition and its preparation method and application for treating the proliferation of mammary gland 李娜 2018-09-07 CN claimed
CN-108498504-A A kind of pharmaceutical composition and its preparation method and application for treating the proliferation of mammary gland 李娜 2018-09-07 CN disclosed