SCHEMBL2824441

SCHEMBL2824441

CC(O)c1cccc2c1C(=O)NC2=O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.49
ALDH1A1 P00352 4/20 0.49
HPGD P15428 2/20 0.49
HSD17B10 Q99714 2/20 0.49
GAA P10253 1/20 0.49
GSK3B P49841 2/20 0.43
CASP3 P42574 6/20 0.43
CASP7 P55210 3/20 0.42
CASP2 P42575 2/20 0.42
CASP6 P55212 2/20 0.42
CASP8 Q14790 2/20 0.42
PARP1 P09874 5/20 0.41
GSK3A P49840 1/20 0.37
CDK5 Q00535 1/20 0.37
CDK5R1 Q15078 1/20 0.37
ANPEP P15144 1/20 0.36
DPP4 P27487 1/20 0.36
POLB P06746 3/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Toluene SCHEMBL10921116 0.91 KDM4E (0.42) KDM4EALDH1A1HPGDHSD17B10GAA
SCHEMBL28128763 0.86 KDM4E (0.46) KDM4EALDH1A1HPGDHSD17B10GAA
SCHEMBL166123 0.85 HPGD (0.47) KDM4EALDH1A1HPGDHSD17B10GAA
SCHEMBL28192702 0.82 KDM4E (0.45) KDM4EALDH1A1HPGDHSD17B10GAA
SCHEMBL57295 0.82 KDM4E (0.45) KDM4EALDH1A1HPGDHSD17B10GAA
SCHEMBL27494084 0.82 ALDH1A1 (0.45) KDM4EALDH1A1HPGDHSD17B10GAA
SCHEMBL3351153 0.81 KDM4E (0.49) KDM4EALDH1A1HPGDHSD17B10GAA
SCHEMBL10922052 0.81 KDM4E (0.45) KDM4EALDH1A1HPGDHSD17B10GAA
SCHEMBL10922058 0.81 KDM4E (0.45) KDM4EALDH1A1HPGDHSD17B10GAA
Hydrochloric Acid SCHEMBL10982285 0.81 ALDH1A1 (0.42) KDM4EALDH1A1HPGDHSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10312106-B2 Semiconductor device and method TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD. (TW) 2019-06-04 US claimed
CN-118852100-A Supermolecule compound and preparation method thereof, formaldehyde rapid detection kit containing compound and application method 珠海未来分子科技有限公司 2024-10-29 CN disclosed
US-20210338593-A1 MULTISTAGE DELIVERY OF ACTIVE AGENTS BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2021-11-04 US disclosed
US-20190111000-A1 MULTISTAGE DELIVERY OF ACTIVE AGENTS BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2019-04-18 US disclosed
US-10143658-B2 Multistage delivery of active agents BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2018-12-04 US disclosed
WO-2017132137-A1 COMPOSITE COMPOSITION AND MODIFICATION OF INORGANIC PARTICLES FOR USE IN COMPOSITE COMPOSITIONS CARNEGIE MELLON UNIVERSITY (US) 2017-08-03 WO disclosed
US-20160051481-A1 MULTISTAGE DELIVERY OF ACTIVE AGENTS BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2016-02-25 US disclosed
US-20100267728-A1 3-SUBSTITUTED-1,2,3-TRIAZIN-4-ONE'S AND 3 SUBSTITUTED 1,3-PYRIMIDINONE'S FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES CORTEX PHARMACEUTICALS, INC. (US) 2010-10-21 US disclosed
EP-2195303-A2 3-SUBSTITUTED 1,2,3-TRIAZIN-4-ONE'S AND 3-SUBSTITUTED 1,3-PYRIMIDINONE'S FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES CORTEX PHARMACEUTICALS, INC. (US) 2010-06-16 EP disclosed
EP-2056794-A2 MULTISTAGE DELIVERY OF ACTIVE AGENTS Board Of Regents Of The University Of Texas (US) 2009-05-13 EP disclosed
US-4952664-A Process for producing weather-resistant polycarbonate with triazine-imide chain terminator MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1990-08-28 US disclosed
WO-1989005305-A1 POLYMERS AND POLYMER-PEPTIDE CONJUGATES 3I RESEARCH EXPLOITATION LIMITED (GB) 1989-06-15 WO disclosed
US-4699965-A NITRILE RUBBERS WITH AN N-(R-OXYMETHYL)ACRYLAMIDE MONOMER; GASKETS EAGLE PICHER INDUSTRIES, INC. (US) 1987-10-13 US disclosed
EP-0114534-B1 HEAT CURABLE SOLVENTLESS LIQUID PREPOLYMER EAGLE-PICHER INDUSTRIES, INC. (US) 1987-04-22 EP disclosed
US-4629796-A NITRILE RUBBERS; SOLVENTLESS; GASKETS EAGLE-PICHER INDUSTRIES, INC. (US) 1986-12-16 US disclosed
US-4562008-A AN ALCOHOL IS FORMED DURING CURING STATES EAGLE-PICHER INDUSTRIES, INC. (US) 1985-12-31 US disclosed
US-4536582-A CONTAINING A RUBBER AND UNSATURATED NITRILE EAGLE-PICHER INDUSTRIES, INC. (US) 1985-08-20 US disclosed
US-4529558-A Free radical polymerizable rubber EAGLE-PICHER INDUSTRIES, INC. (US) 1985-07-16 US disclosed
US-4511722-A Process for preparing cyclic N-vinylacylamines BAYER AKTIENGESELLSCHAFT (DE) 1985-04-16 US disclosed
EP-0114534-A2 Heat curable solventless liquid prepolymer EAGLE-PICHER INDUSTRIES, INC. (US) 1984-08-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100267728-A1 3-SUBSTITUTED-1,2,3-TRIAZIN-4-ONE'S AND 3 SUBSTITUTED 1,3-PYRIMIDINONE'S FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES GRIN3A, OPRK1, CHRNA3 KDM4E 2112/4885ALDH1A1 1001/4885HPGD 3896/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.