Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | KDM5A | P29375 | 2/20 | 0.35 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.35 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | CD38 | P28907 | 3/20 | 0.33 |
| ▸ | ASPH | Q12797 | 2/20 | 0.33 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 6/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.31 |
| ▸ | TET3 | O43151 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.31 |
| ▸ | KDM5C | P41229 | 1/20 | 0.31 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.31 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7695328 | 0.81 | KDM4E (0.53) | KDM4EKDM5AKDM3AJMJD1CALDH1A1 | |
| SCHEMBL31000446 | 0.79 | ADORA3 (0.41) | KDM4EKDM5AKDM3AJMJD1CPIM1 | |
| SCHEMBL2042821 | 0.78 | KDM4E (0.38) | KDM4EKDM5AKDM3AJMJD1CALDH1A1 | |
| SCHEMBL30368390 | 0.77 | KMO (0.37) | KDM4EKDM5AKDM3AJMJD1CALDH1A1 | |
| SCHEMBL21173935 | 0.77 | KMO (0.37) | KDM4EKDM5AKDM3AJMJD1CALDH1A1 | |
| SCHEMBL3053770 | 0.77 | LMNA (0.39) | KDM4EKDM5AKDM3AJMJD1CALDH1A1 | |
| SCHEMBL14294143 | 0.75 | KDM4E (0.35) | KDM4EKDM5AKDM3AJMJD1CALDH1A1 | |
| SCHEMBL14192611 | 0.75 | SORT1 (0.39) | KDM4EKDM5AKDM3AJMJD1CALDH1A1 | |
| SCHEMBL19361039 | 0.75 | KDM4E (0.33) | KDM4EKDM5AKDM3AJMJD1CASPH | |
| SCHEMBL27287238 | 0.75 | MAPT (0.45) | KDM4EKDM3AALDH1A1ALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108473478-A | TBK/IKK inhibitor compounds and uses thereof | 默克专利有限公司 | 2018-08-31 | — | — | CN | disclosed |