Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13614885 | 0.77 | AKT1 (0.49) | LMNAAKT1AKT2TDP1DHODH | |
| SCHEMBL971895 | 0.76 | LMNA (0.62) | LMNATDP1PDE10ATSHRNUDT1 | |
| SCHEMBL13990742 | 0.76 | LMNA (0.50) | LMNAAKT1AKT2TDP1PDE10A | |
| SCHEMBL13222013 | 0.76 | ATM (0.55) | LMNATDP1TSHRNUDT1KDM4E | |
| SCHEMBL27810976 | 0.74 | LMNA (0.61) | LMNATDP1PDE10ATSHRNUDT1 | |
| SCHEMBL28239158 | 0.74 | LMNA (0.61) | LMNATDP1PDE10ATSHRNUDT1 | |
| SCHEMBL13758058 | 0.72 | PDE10A (0.60) | LMNATDP1PDE10ATSHRNUDT1 | |
| SCHEMBL13078944 | 0.72 | AKT1 (0.42) | LMNAAKT1AKT2TDP1TSHR | |
| SCHEMBL28158232 | 0.72 | LMNA (0.57) | LMNATDP1PDE10ATSHRNUDT1 | |
| SCHEMBL28048083 | 0.71 | LMNA (0.49) | LMNATDP1PDE10ATSHRNUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108558927-B | Silicon stereocenter chiral compound and synthesis method thereof | 杭州师范大学 | 2020-06-19 | — | — | CN | claimed |
| CN-108558927-B | Silicon stereocenter chiral compound and synthesis method thereof | 杭州师范大学 | 2020-06-19 | — | — | CN | disclosed |
| CN-108558927-A | A kind of silicon Stereocenter chipal compounds and its synthetic method | 杭州师范大学 | 2018-09-21 | — | — | CN | disclosed |