Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | GRM5 | P41594 | 6/20 | 0.44 |
| ▸ | GBA1 | P04062 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826109 | 0.77 | GRM5 (0.47) | RAB9ANPC1GRM5GBA1KMT2A | |
| SCHEMBL2824734 | 0.77 | RAB9A (0.46) | RAB9ANPC1KMT2AMEN1MAPT | |
| SCHEMBL2826591 | 0.76 | GRM5 (0.46) | RAB9ANPC1GRM5GBA1KMT2A | |
| SCHEMBL2830506 | 0.75 | GRM5 (0.48) | RAB9ANPC1GRM5GBA1KMT2A | |
| SCHEMBL2829267 | 0.75 | GRM5 (0.55) | RAB9ANPC1GRM5GBA1KMT2A | |
| SCHEMBL2830253 | 0.74 | GRM5 (0.51) | RAB9ANPC1GRM5KMT2A | |
| SCHEMBL2827599 | 0.74 | GRM5 (0.46) | RAB9ANPC1GRM5KMT2ASMN1; SMN2 | |
| SCHEMBL2824785 | 0.74 | GRM5 (0.70) | RAB9ANPC1GRM5GBA1KMT2A | |
| SCHEMBL2826581 | 0.73 | GRM5 (0.50) | RAB9ANPC1GRM5GBA1KMT2A | |
| SCHEMBL2827914 | 0.72 | GRM5 (0.47) | RAB9ANPC1GRM5GBA1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |