Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 3/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2821762 | 0.91 | PTGS2 (0.45) | PIK3CAPIK3CGMEN1LMNAKMT2A | |
| SCHEMBL2824583 | 0.89 | NCF1 (0.43) | PIK3CAPIK3CGMEN1LMNAKMT2A | |
| SCHEMBL2824696 | 0.80 | MEN1 (0.47) | JAK2JAK3PTK2AKR1C3MEN1 | |
| SCHEMBL2823193 | 0.79 | FABP3 (0.45) | MEN1LMNAKMT2AALDH1A1MAPT | |
| SCHEMBL2829017 | 0.77 | PTGS2 (0.43) | KIF18APTGS2 | |
| SCHEMBL2821527 | 0.76 | PTGS2 (0.45) | KIF18APTGS2 | |
| SCHEMBL2826443 | 0.75 | NR1H2 (0.35) | PTGS2 | |
| SCHEMBL2820850 | 0.75 | HRH4 (0.36) | PTGS2 | |
| SCHEMBL2824985 | 0.74 | HPGD (0.42) | MTORPIK3CAPIK3CGRAF1BRAF | |
| SCHEMBL2826068 | 0.74 | NPSR1 (0.43) | MEN1LMNAKMT2AMOKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |