SCHEMBL28248573

SCHEMBL28248573

Brc1ccc(C([C](c2ccccc2)c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
S1PR3 Q99500 1/20 0.49
HTR2A P28223 1/20 0.48
TDP1 Q9NUW8 2/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
CNR1 P21554 4/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
SLC6A2 P23975 1/20 0.45
SLC6A4 P31645 1/20 0.45
SLC6A3 Q01959 1/20 0.45
CNR2 P34972 2/20 0.43
ALDH1A1 P00352 3/20 0.42
LMNA P02545 2/20 0.42
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8279 0.87 TDP1 (0.58) TDP1L3MBTL1ALDH1A1LMNAHDAC3
SCHEMBL16807288 0.80 L3MBTL1 (0.77) MEN1KMT2AS1PR3HTR2ATDP1
SCHEMBL16799032 0.79 CES2 (0.47) MEN1KMT2ATDP1L3MBTL1CNR1
SCHEMBL2842478 0.77 MEN1 (0.59) MEN1KMT2AS1PR3HTR2ATDP1
SCHEMBL6984913 0.75 TDP1 (0.47) MEN1KMT2ATDP1L3MBTL1SMN1; SMN2
SCHEMBL6691326 0.73 KMT2A (0.56) MEN1KMT2AS1PR3HTR2ATDP1
SCHEMBL7758852 0.73 MEN1 (0.77) MEN1KMT2AS1PR3HTR2ATDP1
SCHEMBL477648 0.73 HTR2A (0.56) MEN1KMT2AS1PR3HTR2ATDP1
SCHEMBL11604717 0.73 SLC6A2 (0.59) MEN1KMT2AS1PR3HTR2ATDP1
SCHEMBL3858148 0.73 HTR2A (0.56) MEN1KMT2AS1PR3HTR2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108727277-A A kind of singlet oxygen high selectivity aggregation inducing chemiluminescence probe and its preparation method and application 陕西师范大学 2018-11-02 CN claimed