Sugi Predict

Sugi Predict / Compounds / SCHEMBL477648

SCHEMBL477648

SCHEMBL477648

OC(c1ccccc1)c1ccc(Br)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTR2A P28223 1/20 0.56
▸ SLC6A2 P23975 1/20 0.50
▸ SLC6A4 P31645 1/20 0.50
▸ SLC6A3 Q01959 1/20 0.50
▸ SMN1; SMN2 Q16637 2/20 0.48
▸ ALDH1A1 P00352 3/20 0.48
▸ TDP1 Q9NUW8 1/20 0.48
▸ MAPK1 P28482 1/20 0.46
▸ MEN1 O00255 3/20 0.46
▸ KMT2A Q03164 3/20 0.46
▸ CA12 O43570 1/20 0.46
▸ CA1 P00915 1/20 0.46
▸ CA2 P00918 1/20 0.46
▸ CA9 Q16790 1/20 0.46
▸ CA14 Q9ULX7 1/20 0.46
▸ S1PR3 Q99500 1/20 0.46
▸ L3MBTL1 Q9Y468 1/20 0.45
▸ IGF1R P08069 2/20 0.45
▸ IDO1 P14902 1/20 0.44
▸ CNR1 P21554 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3858148 1.00 HTR2A (0.56) HTR2ASLC6A2SLC6A4SLC6A3SMN1; SMN2
SCHEMBL2268223 0.89 CYP2A6 (0.50) HTR2ASLC6A2SLC6A4SLC6A3ALDH1A1
SCHEMBL11642923 0.89 ALDH1A1 (0.65) HTR2ASLC6A2SLC6A4SLC6A3SMN1; SMN2
SCHEMBL8671295 0.87 SMN1; SMN2 (0.58) SMN1; SMN2MAPK1CA12CA1CA2
SCHEMBL11604717 0.85 SLC6A2 (0.59) HTR2ASLC6A2SLC6A4SLC6A3ALDH1A1
Diphenylmethanol SCHEMBL41571 0.84 SMN1; SMN2 (0.61) SMN1; SMN2MAPK1CA12CA1CA2
Diphenylmethanol SCHEMBL10868602 0.84 SMN1; SMN2 (0.61) SMN1; SMN2MAPK1CA12CA1CA2
Diphenylmethanol SCHEMBL6434457 0.84 SMN1; SMN2 (0.61) SMN1; SMN2MAPK1CA12CA1CA2
Diphenylmethanol SCHEMBL11564700 0.84 SMN1; SMN2 (0.61) SMN1; SMN2MAPK1CA12CA1CA2
SCHEMBL3359903 0.83 IGF1R (0.46) HTR2ASLC6A2SLC6A4SLC6A3L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119528773-A N-alkylation method of sulfonamide compound 赣南医科大学 2025-02-28 — — CN claimed
CN-116284046-A Ballon Sha Wei derivative, and preparation method and application thereof 山东新华制药股份有限公司 2023-06-23 — — CN claimed
CN-116023209-A Synthesis method of intermediate and process for preparing bifonazole 重庆西南制药二厂有限责任公司 2023-04-28 — — CN claimed
CN-112517060-B Catalyst, application and synthesis method of 4-hydroxycoumarin derivative 山东农业大学 2022-03-25 — — CN claimed
EP-2267064-B1 Hydrophobic fluorinated polymer surfaces UNIV MARBURG PHILIPPS (DE) 2013-06-26 — — EP claimed
EP-2565183-A1 Glycine transporter-1 inhibitors Amgen Inc. (US) 2013-03-06 — — EP claimed
US-12595243-B2 Modulators of extracellular signal-regulated kinase GEN1E LIFESCIENCES INC. (US) 2026-04-07 — — US disclosed
US-20250136571-A1 MODULATORS OF EXTRACELLULAR SIGNAL-REGULATED KINASE GEN1E LIFESCIENCES INC. 2025-05-01 — — US disclosed
CN-119528773-A N-alkylation method of sulfonamide compound 赣南医科大学 2025-02-28 — — CN disclosed
CN-116284046-A Ballon Sha Wei derivative, and preparation method and application thereof 山东新华制药股份有限公司 2023-06-23 — — CN disclosed
CN-113004236-B Method for synthesizing 3-methylenebenzofuran-1 (3H) -one compound 东华理工大学 2023-05-19 — — CN disclosed
CN-116023209-A Synthesis method of intermediate and process for preparing bifonazole 重庆西南制药二厂有限责任公司 2023-04-28 — — CN disclosed
CN-115677480-A TiO for preparing acid by selectively oxidizing primary alcohol under mild condition 2 Method for NaBr photocatalysis system 东南大学 2023-02-03 — — CN disclosed
EP-1461041-A2 PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF ANTIVIRAL NUCLEOSIDES Pharmasset Ltd. (BB) 2004-09-29 — — EP disclosed
WO-2004022526-A1 CATHEPSIN CYSTEINE PROTEASE INHIBITORS MERCK FROSST CANADA & CO. (CA) 2004-03-18 — — WO disclosed
US-20030162992-A1 Reacting a 2,2-dialkoxyethyl halide with an appropriate carboxylate compound to obtain acetal compound; hydrolyzing the acetal to form the alpha -acyloxyacetaldehyde PHARMASSET, INC. 2003-08-28 — — US disclosed
WO-2003051298-A2 PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF ANTIVIRAL NUCLEOSIDES PHARMASSET LTD. (BB) 2003-06-26 — — WO disclosed
EP-0003923-B1 SUPPORT-ENZYME COMPLEXES AND METHOD FOR PREPARING THEM RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1982-10-20 — — EP disclosed
US-4258133-A Enzyme-support complexes RHONE-POULENC INDUSTRIES (FR) 1981-03-24 — — US disclosed
EP-0003923-A1 Support-enzyme complexes and method for preparing them RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1979-09-05 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250136571-A1 MODULATORS OF EXTRACELLULAR SIGNAL-REGULATED KINASE MAP3K20, MAP3K6, CDC42BPG HTR2A 3442/4885SLC6A2 4855/4885SLC6A4 4828/4885
US-20030162992-A1 Reacting a 2,2-dialkoxyethyl halide with an appropriate carboxylate compound to obtain acetal compound; hydrolyzing the acetal to form the alpha -acyloxyacetaldehyde DERA, DPYD, DHPS HTR2A 2291/4885SLC6A2 3539/4885SLC6A4 3829/4885
US-12595243-B2 Modulators of extracellular signal-regulated kinase CDC42BPG, GRK3, ERBB2 HTR2A 3578/4885SLC6A2 4768/4885SLC6A4 4660/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.