Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16799032 | 0.87 | CES2 (0.47) | TDP1L3MBTL1LMNACES2CES1 | |
| SCHEMBL6984913 | 0.87 | TDP1 (0.47) | TDP1L3MBTL1LMNAHDAC3HDAC4 | |
| SCHEMBL8429409 | 0.79 | CES2 (0.53) | L3MBTL1CES2CES1POLBALDH1A1 | |
| SCHEMBL10740818 | 0.79 | L3MBTL1 (0.54) | TDP1L3MBTL1LMNACES2CES1 | |
| SCHEMBL5941218 | 0.77 | CES2 (0.56) | TDP1L3MBTL1CES2CES1POLB | |
| SCHEMBL1383906 | 0.76 | LMNA (0.60) | TDP1L3MBTL1LMNACES2CES1 | |
| SCHEMBL5013786 | 0.74 | TDP1 (0.54) | TDP1L3MBTL1LMNACES2CES1 | |
| SCHEMBL16062547 | 0.74 | L3MBTL1 (0.54) | TDP1L3MBTL1LMNACES2CES1 | |
| SCHEMBL11533456 | 0.74 | L3MBTL1 (0.54) | TDP1L3MBTL1LMNACES2CES1 | |
| SCHEMBL2927912 | 0.74 | L3MBTL1 (1.00) | TDP1L3MBTL1LMNACES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 262 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150246931-A1 | PROCESS FOR THE PREPARATION OF TAZOBACTAM | HOSPIRA, INC. (US) | 2015-09-03 | — | — | US | claimed |
| US-7569599-B2 | Intermediates for the production of optically active cyclopropylamine derivatives and process for the production of the intermediates | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2009-08-04 | — | — | US | claimed |
| CN-109053818-A | The preparation of fluorinated alpha-diimine nickel (II) complex replaced containing ortho position benzhydryl for vinyl polymerization | 常州大学 | 2018-12-21 | — | — | CN | disclosed |
| US-10150742-B2 | Substituted heterocyclic compounds for treating or preventing viral infections | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-12-11 | — | — | US | disclosed |
| US-20170267659-A1 | METHOD FOR PRODUCING 2-PYRIDONE COMPOUND | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2017-09-21 | — | — | US | disclosed |
| US-9708287-B2 | Chiral compounds, compositions, products and methods employing same | CAYMAN CHEMICAL COMPANY INCORPORATED (US) | 2017-07-18 | — | — | US | disclosed |
| US-9643977-B2 | Necroptosis inhibitors and methods of use therefor | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-05-09 | — | — | US | disclosed |
| EP-3144305-A1 | METHOD FOR PRODUCING 2-PYRIDONE COMPOUND | Nissan Chemical Industries, Ltd. (JP) | 2017-03-22 | — | — | EP | disclosed |
| US-9540372-B2 | Pyrido[2,3-b]pyrazin-8-substituted compounds and their use | INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE) (GB) | 2017-01-10 | — | — | US | disclosed |
| US-9469609-B2 | Synthesis of pyrrolidine compounds | ZEALAND PHARMA A/S (DK) | 2016-10-18 | — | — | US | disclosed |
| US-9452992-B2 | Small molecule inhibitors of ebola and lassa fever viruses | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-09-27 | — | — | US | disclosed |
| US-4640798-A | Intermediates for the preparation of penicillin and cephalosporin compounds | LILLY INDUSTRIES LTD. (GB) | 1987-02-03 | — | — | US | disclosed |
| US-4558124-A | Preparation of cephalosporin intermediate compounds | LILLY INDUSTRIES LIMITED (GB) | 1985-12-10 | — | — | US | disclosed |
| US-4500526-A | ANTIBIOTICS, BACTERICIDES | BRISTOL-MYERS COMPANY (US) | 1985-02-19 | — | — | US | disclosed |
| US-4474879-A | Process for 3-hydroxymethyl cephalosporin sulfones | ELI LILLY AND COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
| US-4459405-A | Desacetylcephalosporin sulfones | ELI LILLY AND COMPANY (US) | 1984-07-10 | — | — | US | disclosed |
| EP-0109300-A2 | Desacetylcephalosporin sulfones | ELI LILLY AND COMPANY (US) | 1984-05-23 | — | — | EP | disclosed |
| US-4008229-A | Halo substituted β-lactam antibiotics | ELI LILLY AND COMPANY (US) | 1977-02-15 | — | — | US | disclosed |
| US-4001226-A | 3-(SUBSTITUTED)CARBONYLAMINO CEPHEM DERIVATIVES | ELI LILLY AND COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
| US-3953440-A | Deacetoxycephalosporins via penicillin sulfoxide rearrangement | ELI LILLY AND COMPANY (US) | 1976-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10150742-B2 | Substituted heterocyclic compounds for treating or preventing viral infections | HAVCR2, DDX5, DPYD | TDP1 1113/4885L3MBTL1 2772/4885LMNA 2765/4885 |
| US-20170267659-A1 | METHOD FOR PRODUCING 2-PYRIDONE COMPOUND | CYP2B6, CYP2D6, CYP2J2 | TDP1 3517/4885L3MBTL1 4881/4885LMNA 3321/4885 |
| US-20150246931-A1 | PROCESS FOR THE PREPARATION OF TAZOBACTAM | FDPS, BPGM, MPST | TDP1 4516/4885L3MBTL1 4381/4885LMNA 3509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.