SCHEMBL28249659

SCHEMBL28249659

C#C[C@@H](OCCO)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.41

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.35
CES1 P23141 1/20 0.35
AKR1C3 P42330 2/20 0.34
AKR1C2 P52895 2/20 0.34
FFAR1 O14842 3/20 0.33
ACP3 P15309 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28249660 1.00 CES2 (0.35) CES2CES1AKR1C3AKR1C2FFAR1
SCHEMBL28249648 0.82 SLC6A3 (0.36)
SCHEMBL28249646 0.82 SLC6A3 (0.36)
SCHEMBL28865707 0.79 PYCR1 (0.36)
SCHEMBL28865706 0.79 PYCR1 (0.36)
SCHEMBL25207508 0.78 ALDH1A1 (0.39)
SCHEMBL28865641 0.78 ALDH1A1 (0.39)
SCHEMBL28684586 0.78 PDE2A (0.41) CES2CES1AKR1C3AKR1C2ACP3
SCHEMBL28250343 0.76 AOC3 (0.38)
SCHEMBL28250340 0.76 AOC3 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108722484-B Composition for preparing propargyl ether 四川大学 2021-04-27 CN disclosed
CN-108722484-A A kind of composition preparing propargyl ether 四川大学 2018-11-02 CN disclosed