Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GCK | P35557 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826464 | 0.86 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2MEN1LMNA | |
| SCHEMBL2829743 | 0.85 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2MEN1MAPT | |
| SCHEMBL2828877 | 0.85 | RAB9A (0.52) | NPC1RAB9ASMN1; SMN2MEN1LMNA | |
| SCHEMBL2824780 | 0.84 | ALDH1A1 (0.44) | NPC1RAB9ASMN1; SMN2MEN1MAPT | |
| SCHEMBL2828556 | 0.81 | MAOB (0.46) | NPC1RAB9AMEN1LMNAMAPT | |
| SCHEMBL2824997 | 0.81 | GRM5 (0.48) | NPC1RAB9ASMN1; SMN2MAPTHPGD | |
| SCHEMBL2829479 | 0.80 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2MEN1MAPT | |
| SCHEMBL2829552 | 0.78 | RAB9A (0.47) | NPC1RAB9ASMN1; SMN2MEN1LMNA | |
| SCHEMBL2827802 | 0.77 | SCD (0.48) | NPC1RAB9ASMN1; SMN2MEN1MAPT | |
| SCHEMBL2826277 | 0.75 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |