Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 8/20 | 0.45 |
| ▸ | NPC1 | O15118 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GCK | P35557 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828877 | 0.87 | RAB9A (0.52) | SCDRAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL2830110 | 0.83 | RAB9A (0.46) | RAB9ANPC1ALDH1A1MAPTKDM4E | |
| SCHEMBL2829552 | 0.82 | RAB9A (0.47) | SCDRAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL2824997 | 0.80 | GRM5 (0.48) | RAB9ANPC1HPGDSMN1; SMN2MAPT | |
| SCHEMBL2830217 | 0.79 | RAB9A (0.41) | RAB9ANPC1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL2828968 | 0.78 | MAPT (0.44) | RAB9ANPC1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL2828532 | 0.78 | NPC1 (0.44) | RAB9ANPC1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL2830126 | 0.77 | NPC1 (0.42) | RAB9ANPC1HPGDSMN1; SMN2MAPT | |
| SCHEMBL2828993 | 0.77 | MAPT (0.51) | RAB9ANPC1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL2826011 | 0.75 | ALDH1A1 (0.41) | RAB9ANPC1HPGDSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |