Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.44 |
| ▸ | NAMPT | P43490 | 4/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827389 | 0.88 | GRM5 (0.51) | GRM5NAMPTPIK3CGLMNAKDM4E | |
| SCHEMBL2825843 | 0.86 | GRM5 (0.58) | GRM5NAMPTSMN1; SMN2 | |
| SCHEMBL2824997 | 0.84 | GRM5 (0.48) | GRM5NAMPTPIK3CGKDM4EMAPT | |
| SCHEMBL15664555 | 0.83 | GRM5 (0.50) | GRM5NAMPTPIK3CGLMNAMETAP2 | |
| SCHEMBL2829501 | 0.82 | GRM5 (0.45) | GRM5NAMPTLMNASMN1; SMN2 | |
| SCHEMBL2828918 | 0.82 | GRM5 (0.44) | GRM5NAMPTPIK3CGLMNASMN1; SMN2 | |
| SCHEMBL2831112 | 0.81 | IRAK4 (0.46) | GRM5NAMPTLMNAMAPTHPGD | |
| SCHEMBL2832364 | 0.81 | GRM5 (0.55) | GRM5NAMPTMAPTPIK3CA | |
| SCHEMBL2829743 | 0.81 | NPC1 (0.42) | GRM5MAPTCASP7SMN1; SMN2 | |
| SCHEMBL2828432 | 0.79 | GRM5 (0.42) | GRM5NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |