Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 3/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825321 | 0.90 | KCNH2 (0.45) | KCNH2GSK3BKDM4EHPGDALDH1A1 | |
| SCHEMBL14940560 | 0.89 | KCNH2 (0.49) | KCNH2GSK3BKDM4EHPGDALDH1A1 | |
| SCHEMBL2601622 | 0.89 | KCNH2 (0.44) | KCNH2GSK3BKDM4EHPGDALDH1A1 | |
| SCHEMBL2601633 | 0.89 | KCNH2 (0.44) | KCNH2GSK3BKDM4EHPGDALDH1A1 | |
| SCHEMBL13945289 | 0.87 | ADRB2 (0.43) | KCNH2GSK3BKDM4EHPGDALDH1A1 | |
| SCHEMBL3129389 | 0.86 | KDM4E (0.51) | KCNH2GSK3BKDM4EHPGDALDH1A1 | |
| SCHEMBL116421 | 0.85 | KCNH2 (0.60) | KCNH2GSK3BKDM4EHPGDALDH1A1 | |
| SCHEMBL116273 | 0.85 | ADRB2 (0.52) | KCNH2GSK3BKDM4EHPGDALDH1A1 | |
| SCHEMBL13790031 | 0.85 | KDM4E (0.49) | KCNH2GSK3BKDM4EHPGDALDH1A1 | |
| Fluoride SCHEMBL4027252 | 0.84 | KCNH2 (0.58) | KCNH2GSK3BKDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2226322-B1 | IMIDAZOLE CARBONYL COMPOUND | DAIICHI SANKYO CO LTD (JP) | 2015-01-21 | — | — | EP | disclosed |
| US-8927588-B2 | Imidazole carbonyl compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-01-06 | — | — | US | disclosed |
| US-20140073622-A1 | IMIDAZOLE CARBONYL COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-03-13 | — | — | US | disclosed |
| US-8536197-B2 | Imidazole carbonyl compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-09-17 | — | — | US | disclosed |
| US-7902227-B2 | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents | JANSSEN PHARMACEUTICA NV. (BE) | 2011-03-08 | — | — | US | disclosed |
| US-7902227-B2 | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents | JANSSEN PHARMACEUTICA NV. (BE) | 2011-03-08 | — | — | US | disclosed |
| US-7902227-B2 | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents | JANSSEN PHARMACEUTICA NV. (BE) | 2011-03-08 | — | — | US | disclosed |
| US-20100311966-A1 | IMIDAZOLE CARBONYL COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-12-09 | — | — | US | disclosed |
| EP-2226322-A1 | IMIDAZOLE CARBONYL COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2010-09-08 | — | — | EP | disclosed |
| WO-2010093341-A1 | C-7 ISOXAZOLINYL QUINOLONE/NAPHTHYRIDINE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-08-19 | — | — | WO | disclosed |
| US-20090029980-A1 | C-7 Isoxazolinyl Quinolone / Naphthyridine Derivatives Useful as Antibacterial Agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-29 | — | — | US | disclosed |
| US-20090029980-A1 | C-7 Isoxazolinyl Quinolone / Naphthyridine Derivatives Useful as Antibacterial Agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-29 | — | — | US | disclosed |
| US-20090029980-A1 | C-7 Isoxazolinyl Quinolone / Naphthyridine Derivatives Useful as Antibacterial Agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311966-A1 | IMIDAZOLE CARBONYL COMPOUND | TOP1, TOP2B, TOP2A | KCNH2 2740/4885GSK3B 917/4885KDM4E 206/4885 |
| US-20090029980-A1 | C-7 Isoxazolinyl Quinolone / Naphthyridine Derivatives Useful as Antibacterial Agents | CASP7, CYP3A7, NQO2 | KCNH2 1777/4885GSK3B 984/4885KDM4E 3311/4885 |
| US-20140073622-A1 | IMIDAZOLE CARBONYL COMPOUND | TOP1, TOP2B, TOP2A | KCNH2 2469/4885GSK3B 298/4885KDM4E 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.