Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 6/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827841 | 0.87 | NR1H2 (0.41) | NR1H2NR1H3PTGS2 | |
| SCHEMBL2829123 | 0.87 | ENPP1 (0.40) | — | |
| SCHEMBL2821849 | 0.87 | GAA (0.46) | NR1H2NR1H3 | |
| SCHEMBL2825639 | 0.85 | NR1H2 (0.40) | NR1H2NR1H3PTGS2 | |
| SCHEMBL2829017 | 0.82 | PTGS2 (0.43) | NR1H2PTGS2 | |
| SCHEMBL2821494 | 0.79 | PRNP (0.57) | PTGS2 | |
| SCHEMBL2821151 | 0.79 | KIF18A (0.38) | NR1H2PTGS2 | |
| SCHEMBL2826443 | 0.78 | NR1H2 (0.35) | NR1H2NR1H3PTGS2 | |
| SCHEMBL2822428 | 0.77 | GPR119 (0.36) | NR1H2NR1H3PTGS2 | |
| SCHEMBL2822519 | 0.77 | PTGS2 (0.34) | NR1H2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |