Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.58 |
| ▸ | RAB9A | P51151 | 8/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GBA1 | P04062 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2824990 | 0.93 | RAB9A (0.51) | NPC1RAB9AKMT2AMEN1GRM5 | |
| SCHEMBL2830797 | 0.87 | RAB9A (0.51) | NPC1RAB9AKMT2AMEN1GRM5 | |
| SCHEMBL2826737 | 0.87 | RAB9A (0.56) | NPC1RAB9AKMT2AMEN1GRM5 | |
| SCHEMBL2830129 | 0.86 | CYP1A2 (0.44) | NPC1RAB9AKMT2AMEN1GRM5 | |
| SCHEMBL2833180 | 0.85 | RAB9A (0.54) | NPC1RAB9AKMT2AMEN1GRM5 | |
| SCHEMBL2826464 | 0.84 | NPC1 (0.58) | NPC1RAB9AKMT2AMEN1GRM5 | |
| SCHEMBL2825977 | 0.84 | GRM5 (0.50) | NPC1RAB9AKMT2AMEN1GRM5 | |
| SCHEMBL2825843 | 0.83 | GRM5 (0.58) | NPC1RAB9AKMT2AMEN1GRM5 | |
| SCHEMBL2831443 | 0.81 | RAB9A (0.49) | NPC1RAB9AKMT2AMEN1GRM5 | |
| SCHEMBL2829349 | 0.80 | NPC1 (0.43) | NPC1RAB9AKMT2AMEN1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |