Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 8/20 | 0.43 |
| ▸ | NPC1 | O15118 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830797 | 0.87 | RAB9A (0.51) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL2826737 | 0.87 | RAB9A (0.56) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2826324 | 0.86 | NPC1 (0.58) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL2826464 | 0.84 | NPC1 (0.58) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL2825977 | 0.84 | GRM5 (0.50) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL2825843 | 0.83 | GRM5 (0.58) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2824990 | 0.83 | RAB9A (0.51) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL2833180 | 0.82 | RAB9A (0.54) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL2831443 | 0.81 | RAB9A (0.49) | CYP1A2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2830006 | 0.79 | RAB9A (0.44) | CYP1A2RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |