Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.46 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 3/20 | 0.43 |
| ▸ | RXRB | P28702 | 3/20 | 0.43 |
| ▸ | RXRG | P48443 | 2/20 | 0.41 |
| ▸ | RORB | Q92753 | 3/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ICMT | O60725 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28260236 | 0.84 | RXRA (0.51) | CHUKTMPRSS4CLK1DYRK1ARXRA | |
| SCHEMBL8336975 | 0.82 | CHUK (0.66) | CHUKTMPRSS4CASP1DHODHPARP1 | |
| SCHEMBL8337607 | 0.81 | KIF11 (0.57) | CHUKTMPRSS4DHODHPARP1P2RX1 | |
| SCHEMBL28195533 | 0.77 | CHUK (0.67) | CHUKCLK1DYRK1ACASP1 | |
| SCHEMBL3992190 | 0.76 | RXRA (0.65) | RXRARXRBRXRG | |
| SCHEMBL28260233 | 0.75 | CHUK (0.53) | CHUKCLK1DYRK1AKIF11 | |
| SCHEMBL27395327 | 0.75 | CES2 (0.52) | CHUKTMPRSS4CASP1P2RX1 | |
| SCHEMBL28260235 | 0.74 | CHUK (0.51) | CHUKTMPRSS4CLK1DYRK1ARORB | |
| SCHEMBL28217088 | 0.74 | KIF11 (0.59) | RXRARXRBRXRGNOTUMKIF11 | |
| SCHEMBL409519 | 0.74 | CHUK (0.58) | CHUKCLK1DYRK1ACASP1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109512805-A | For treating the compound of the disease of aquaporin mediation | 埃罗米克斯公司 | 2019-03-26 | — | — | CN | disclosed |
| CN-104602682-B | Compounds for the treatment of aquaporin mediated diseases | 埃罗米克斯公司 | 2018-12-14 | — | — | CN | disclosed |