Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 2/20 | 0.55 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | PLG | P00747 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | PLAT | P00750 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.48 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8336975 | 0.86 | CHUK (0.66) | KIF11PARP1CHUKMCL1ACMSD | |
| SCHEMBL28260236 | 0.82 | RXRA (0.51) | KIF11PARP1CHUKDHODHP2RX1 | |
| SCHEMBL27395327 | 0.82 | CES2 (0.52) | CHUKKDM4EADRB2ADRB1ADRB3 | |
| SCHEMBL28260232 | 0.81 | CHUK (0.49) | KIF11PARP1CHUKDHODHP2RX1 | |
| SCHEMBL9202951 | 0.81 | MKNK1 (0.56) | KIF11PARP1PLGPLAUPLAT | |
| SCHEMBL4724483 | 0.80 | PARP1 (0.59) | KIF11PARP1PLGPLAUPLAT | |
| SCHEMBL5308985 | 0.79 | ACMSD (0.72) | CHUKKDM4EMCL1ACMSDDHFR | |
| SCHEMBL28260234 | 0.78 | TMPRSS4 (0.49) | KIF11CHUKKDM4EMCL1ACMSD | |
| SCHEMBL3727414 | 0.78 | PLG (0.60) | KIF11PARP1PLGPLAUPLAT | |
| SCHEMBL11165545 | 0.77 | PARP1 (0.53) | KIF11PARP1PLGPLAUPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014844-A2 | ARYL AND HETEROARYL COMPOUNDS AND METHODS TO MODULATE COAGULATION | TRANSTECH PHARMA, INC. (US) | 2004-02-19 | — | — | WO | disclosed |