Sugi Predict

Sugi Predict / Compounds / SCHEMBL2826285

SCHEMBL2826285

SCHEMBL2826285

NC(=O)c1cccc(C(F)(F)F)n1

nearest known ligand 0.67

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ P2RX7 Q99572 1/20 0.67
▸ AHR P35869 1/20 0.50
▸ KMT2A Q03164 1/20 0.44
▸ PGK1 P00558 1/20 0.44
▸ PGK2 P07205 1/20 0.44
▸ TGFBR1 P36897 4/20 0.43
▸ PIM1 P11309 1/20 0.43
▸ SCN9A Q15858 2/20 0.43
▸ JAK2 O60674 1/20 0.43
▸ IRAK4 Q9NWZ3 3/20 0.42
▸ TAS2R14 Q9NYV8 1/20 0.42
▸ PARP1 P09874 1/20 0.41
▸ SYK P43405 2/20 0.40
▸ GRM2 Q14416 1/20 0.40
▸ FPR2 P25090 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Formic Acid SCHEMBL30892563 0.93 P2RX7 (0.59) P2RX7AHRKMT2APGK1PGK2
SCHEMBL27737055 0.86 P2RX7 (0.68) P2RX7AHRPGK1PGK2IRAK4
SCHEMBL29502443 0.85 P2RX7 (0.50) P2RX7AHRKMT2APGK1PGK2
SCHEMBL22835396 0.85 P2RX7 (0.50) P2RX7AHRKMT2APGK1PGK2
SCHEMBL22836048 0.85 P2RX7 (0.50) P2RX7AHRKMT2APGK1PGK2
SCHEMBL29375278 0.82 P2RX7 (0.64) P2RX7AHRKMT2APGK1PGK2
SCHEMBL28015459 0.82 P2RX7 (0.64) P2RX7AHRPGK1PGK2IRAK4
SCHEMBL496206 0.82 P2RX7 (0.64) P2RX7AHRKMT2APGK1PGK2
SCHEMBL13043982 0.81 P2RX7 (0.62) P2RX7AHRPGK1PGK2IRAK4
SCHEMBL29799817 0.81 P2RX7 (0.62) P2RX7AHRPGK1PGK2IRAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 222 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4622959-A1 2-AMINO-N-(4-AMINO-3,4-DIOXO-1-(2-OXOPYRROLIDIN-3-YL)BUTAN-2-YL)BENZAMIDE DERIVATIVES AS PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION Merck Sharp & Dohme LLC (US) 2025-10-01 — — EP claimed
CN-120202200-A Oxo-isoindolinyl substituted tetrahydropyrimidinedione-based compounds and applications thereof 标新生物医药科技(上海)有限公司 2025-06-24 — — CN claimed
CN-120051473-A Compounds that inhibit or degrade CDK2 and/or CDK9 and medical uses thereof 韩国化学研究院 2025-05-27 — — CN claimed
CN-118696036-A PARP1 inhibitors 突触活化疗法股份有限公司 2024-09-24 — — CN claimed
WO-2024112621-A1 2-AMINO-N-(4-AMINO-3,4-DIOXO-1-(2-OXOPYRROLIDIN-3-YL)BUTAN-2-YL)BENZAMIDE DERIVATIVES AS PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION MERCK SHARP & DOHME LLC (US) 2024-05-30 — — WO claimed
WO-2024039210-A1 COMPOUNDS FOR INHIBITING OR DECOMPOSING CDK2 AND/OR CDK9, AND MEDICINAL USES THEREOF 한국화학연구원 2024-02-22 — — WO claimed
US-11897863-B2 Indazole amine derivative, preparation method therefor and medical use thereof ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) 2024-02-13 — — US claimed
CN-116133692-A Methods of treating mutant lymphomas 凯麦拉医疗公司 2023-05-16 — — CN claimed
CN-111601790-B Heteroaryl compounds as protein kinase inhibitors 福建海西新药创制股份有限公司 2023-03-31 — — CN claimed
WO-2022155419-A1 INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS ESCAPE Bio, Inc. (US) 2022-07-21 — — WO claimed
US-20110312935-A1 1H-Benz Imidazole-5-Carboxamides As Anti-Inflammatory Agents BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-12-22 — — US claimed
EP-1844044-B1 THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS HOFFMANN LA ROCHE (CH) 2010-07-21 — — EP claimed
WO-2010034796-A1 1H-BENZ IMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-04-01 — — WO claimed
US-7678815-B2 Thiazole-4-carboxyamide derivatives HOFFMANN-LA ROCHE INC. (US) 2010-03-16 — — US claimed
EP-2081905-A2 SULFONYL COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR Boehringer Ingelheim International GmbH (DE) 2009-07-29 — — EP claimed
US-20080039464-A1 Compounds Which Modulate The CB2 Receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-02-14 — — US claimed
WO-2008014199-A2 SULFONYL COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-01-31 — — WO claimed
EP-1844044-A1 THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS F.HOFFMANN-LA ROCHE AG (CH) 2007-10-17 — — EP claimed
US-20060160857-A1 Thiazole-4-carboxyamide derivatives HOFFMANN-LA ROCHE INC. 2006-07-20 — — US claimed
WO-2006074884-A1 THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS F.HOFFMANN-LA ROCHE AG (CH) 2006-07-20 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060160857-A1 Thiazole-4-carboxyamide derivatives GRM1, GRM2, GRIA4 P2RX7 214/4885AHR 2933/4885KMT2A 1012/4885
US-20110312935-A1 1H-Benz Imidazole-5-Carboxamides As Anti-Inflammatory Agents MAPRE2, MAPRE1, H1-4 P2RX7 1117/4885AHR 2830/4885KMT2A 1047/4885
US-20080039464-A1 Compounds Which Modulate The CB2 Receptor CNR2, CNR1, OPRL1 P2RX7 51/4885AHR 386/4885KMT2A 3627/4885
US-11897863-B2 Indazole amine derivative, preparation method therefor and medical use thereof IRAK4, IRAK1, IRAK2 P2RX7 1013/4885AHR 321/4885KMT2A 2281/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.