SCHEMBL28275779

SCHEMBL28275779

C=CCCOc1ccc(C#Cc2ccc(N=C=S)cc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
P2RY6 Q15077 1/20 0.40
ALDH1A1 P00352 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
MIF P14174 1/20 0.35
APP P05067 7/20 0.34
CHRNB2 P17787 1/20 0.33
CHRNB4 P30926 1/20 0.33
CHRNA3 P32297 1/20 0.33
CHRNA7 P36544 1/20 0.33
CHRNA4 P43681 1/20 0.33
FURIN P09958 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
ACACB O00763 4/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28277119 0.85 HAO1 (0.32) ALDH1A1L3MBTL1APP
SCHEMBL24184660 0.80 CYP1A2 (0.46) P2RY6ALDH1A1CHRNB2CHRNB4CHRNA3
SCHEMBL24184663 0.80 CYP2C9 (0.46) P2RY6CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL12437009 0.77 THRB (0.48) P2RY6ALDH1A1L3MBTL1FURINACACB
SCHEMBL19031682 0.76 P2RY6 (0.52) P2RY6ALDH1A1MIFCA1CA2
SCHEMBL24184661 0.76 NQO1 (0.50) P2RY6ALDH1A1ACACB
SCHEMBL19031673 0.73 HSD17B10 (0.48) P2RY6MIFCA1CA2
SCHEMBL24184976 0.72 ACACB (0.49) P2RY6ALDH1A1MIFACACB
SCHEMBL5404636 0.72 ALDH1A1 (0.54) ALDH1A1L3MBTL1FURIN
SCHEMBL5965422 0.72 ALDH1A1 (0.49) ALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106978192-B A kind of high birefringence rate liquid crystal compound and preparation method thereof with and combinations thereof 西安近代化学研究所 2019-02-12 CN disclosed