Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.66 |
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | CCR1 | P32246 | 3/20 | 0.41 |
| ▸ | CCR8 | P51685 | 3/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718956 | 0.83 | KDM4E (0.46) | L3MBTL1KDM4ENPC1RAB9AADORA3 | |
| SCHEMBL9275208 | 0.77 | SLC40A1 (0.50) | L3MBTL1KDM4ENPC1RAB9ACCR1 | |
| SCHEMBL25523414 | 0.74 | KDM4E (0.51) | L3MBTL1KDM4ENPC1RAB9AMET | |
| SCHEMBL20600822 | 0.74 | FEN1 (0.45) | L3MBTL1KDM4ENPC1RAB9AMET | |
| SCHEMBL25522331 | 0.73 | L3MBTL1 (0.50) | L3MBTL1KDM4ENPC1RAB9AMET | |
| SCHEMBL3713624 | 0.73 | PSMD14 (0.62) | L3MBTL1KDM4ENPC1CCR1CCR8 | |
| SCHEMBL14242732 | 0.73 | HSP90AA1 (0.54) | L3MBTL1KDM4ENPC1RAB9ACCR1 | |
| SCHEMBL22271011 | 0.73 | CCR1 (0.45) | L3MBTL1KDM4ENPC1RAB9AADORA3 | |
| SCHEMBL1148265 | 0.73 | CCR1 (0.50) | L3MBTL1KDM4ECCR1CCR8GMNN | |
| SCHEMBL1148955 | 0.73 | CCR1 (0.45) | L3MBTL1KDM4ENPC1RAB9AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106132951-B | quinoline-based kinase inhibitors | 百时美施贵宝公司 | 2019-02-12 | — | — | CN | disclosed |