Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clopamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.45 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.45 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | CA1 | P00915 | 6/20 | 0.47 |
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CA3 | P07451 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clopamide SCHEMBL124598 | 0.82 | KDM4E (1.00) | LMNAHSD17B10KDM4EGLAMAPT | |
| Clopamide SCHEMBL1650071 | 0.82 | KDM4E (1.00) | LMNAHSD17B10KDM4EGLAMAPT | |
| SCHEMBL27462399 | 0.74 | LMNA (0.83) | LMNAHSD17B10KDM4EGLAMAPT | |
| Clopamide SCHEMBL28086094 | 0.71 | LMNA (0.68) | LMNAHSD17B10KDM4EGLAMAPT | |
| Clopamide SCHEMBL28086350 | 0.70 | MAPT (0.66) | LMNAHSD17B10KDM4EGLAMAPT | |
| Clonidine SCHEMBL5983 | 0.67 | ADRA2A (1.00) | LMNAHSD17B10ADRA2AADRA2BADRA2C | |
| Cyclopenthiazide SCHEMBL28279853 | 0.67 | LMNA (0.66) | LMNAHSD17B10KDM4EGLAMAPT | |
| Chlorthalidone SCHEMBL4984541 | 0.67 | CA12 (0.67) | LMNAHSD17B10MAPTCA1CA2 | |
| Clonidine SCHEMBL613364 | 0.66 | ADRA2A (0.97) | LMNAHSD17B10ALDH1A1ADRA2AADRA2B | |
| Clonidine SCHEMBL2231324 | 0.66 | ADRA2A (1.00) | LMNAHSD17B10ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109475645-A | MicroRNA composition and its preparation and application | 先进瑞金医疗技术有限公司 | 2019-03-15 | — | — | CN | disclosed |