Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.73 |
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 6/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | AHR | P35869 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | AKT1 | P31749 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9496511 | 0.84 | LMNA (1.00) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5255345 | 0.84 | LMNA (0.71) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL29898238 | 0.84 | LMNA (0.71) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5083062 | 0.84 | RAB9A (0.72) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL28949487 | 0.84 | LMNA (0.71) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL28309786 | 0.84 | LMNA (0.71) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL2714471 | 0.83 | LMNA (0.70) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL479805 | 0.83 | DHODH (0.76) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL28284428 | 0.82 | LMNA (0.68) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5078978 | 0.81 | MEN1 (0.79) | LMNAMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106061967-B | The nicotinamide compounds replaced through heteroaryl | 百时美施贵宝公司 | 2019-04-19 | — | — | CN | claimed |