Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | MEN1 | O00255 | 7/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.65 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | AHR | P35869 | 1/20 | 0.60 |
| ▸ | DHODH | Q02127 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28282946 | 0.84 | LMNA (0.73) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL5083062 | 0.83 | RAB9A (0.72) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL29898238 | 0.83 | LMNA (0.71) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL5255345 | 0.83 | LMNA (0.71) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL9496511 | 0.83 | LMNA (1.00) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL28949487 | 0.83 | LMNA (0.71) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL2714471 | 0.82 | LMNA (0.70) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL479805 | 0.82 | DHODH (0.76) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL28284428 | 0.81 | LMNA (0.68) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL29421217 | 0.81 | RAB9A (0.73) | LMNAMAPTMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814040-B | The condensed 1,4- dihydro two of inhibitor as thermal excited transcryption factor 1 dislikes ene derivative | 癌症研究科技有限公司 | 2019-07-30 | — | — | CN | disclosed |