Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | MLLT1 | Q03111 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | MARK3 | P27448 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.36 |
| ▸ | STK3 | Q13188 | 1/20 | 0.36 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.36 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29654096 | 0.86 | MMP2 (0.43) | HRH3JAK2ROCK2PRKD3PRKCG | |
| SCHEMBL28797800 | 0.86 | MMP2 (0.43) | HRH3JAK2ROCK2PRKD3PRKCG | |
| SCHEMBL19360618 | 0.82 | IDO1 (0.39) | HRH3JAK2ROCK2PRKD3PRKCG | |
| SCHEMBL19360619 | 0.75 | L3MBTL1 (0.40) | HRH3IRAK1IRAK4GRM2HSD17B10 | |
| SCHEMBL8181089 | 0.71 | HRH3 (0.48) | HRH3LMNANPSR1KDM4EALDH1A1 | |
| SCHEMBL28283531 | 0.71 | PTGER4 (0.42) | CFB | |
| SCHEMBL14972596 | 0.68 | CYP1A2 (0.54) | HRH3SSTR3MAPTLMNANPSR1 | |
| SCHEMBL29746437 | 0.68 | KMT2A (0.51) | HRH3SSTR3MAPTRAB9AKDM4E | |
| SCHEMBL20570792 | 0.68 | HRH3 (0.52) | HRH3LMNANPSR1KDM4EALDH1A1 | |
| SCHEMBL30457877 | 0.68 | HRH3 (0.52) | HRH3LMNANPSR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109485595-A | Indole carboxamides analog derivative, preparation method and its application in medicine that hydrophilic radical replaces | 江苏恒瑞医药股份有限公司 | 2019-03-19 | — | — | CN | disclosed |