Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28797800 | 1.00 | MMP2 (0.43) | MMP2MMP13HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL28283532 | 0.86 | HRH3 (0.37) | HRH3ALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL19360613 | 0.82 | HRH3 (0.44) | MMP2MMP13HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL19360618 | 0.78 | IDO1 (0.39) | HRH3JAK2ROCK2PRKD3PRKCG | |
| SCHEMBL28797793 | 0.75 | PTGER4 (0.42) | ALDH1A1SMN1; SMN2SIRT2SIRT1MAPT | |
| SCHEMBL29654217 | 0.75 | PTGER4 (0.42) | ALDH1A1SMN1; SMN2SIRT2SIRT1MAPT | |
| SCHEMBL21409993 | 0.72 | KDM4E (0.43) | ALDH1A1SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL21409994 | 0.72 | KDM4E (0.43) | ALDH1A1SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL29654185 | 0.72 | HRH3 (0.59) | MMP2MMP13HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL7920888 | 0.70 | ALDH1A1 (0.68) | MMP2MMP13HRH3ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109485595-B | Hydrophilic group substituted indole formamide derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-05-27 | — | — | CN | disclosed |