Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | FPR2 | P25090 | 10/20 | 0.41 |
| ▸ | FPR1 | P21462 | 9/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | FPR3 | P25089 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828120 | 0.89 | KDM4C (0.38) | ALDH1A1IDH1KMT2ANPC1MEN1 | |
| SCHEMBL2828114 | 0.87 | ROCK2 (0.39) | ALDH1A1IDH1ROCK2KMT2ANPC1 | |
| SCHEMBL2826438 | 0.87 | GPR52 (0.39) | ROCK2MAPT | |
| SCHEMBL2825898 | 0.85 | ALDH1A1 (0.51) | ALDH1A1GAAPKMIDH1ROCK2 | |
| SCHEMBL2829346 | 0.83 | KDM4C (0.36) | P2RX7FPR2FPR1 | |
| SCHEMBL2829340 | 0.82 | KDM4C (0.41) | P2RX7 | |
| SCHEMBL2828108 | 0.82 | KDM4C (0.41) | P2RX7FPR2FPR1 | |
| SCHEMBL1997196 | 0.80 | PDE4B (0.34) | P2RX7KMT2AMAPT | |
| SCHEMBL2826007 | 0.80 | KDM4C (0.35) | PKMKMT2AMEN1MAPT | |
| SCHEMBL2828388 | 0.80 | PDE4B (0.39) | ALDH1A1GAAKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |