Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | ADK | P55263 | 2/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 5/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776718 | 0.81 | TDO2 (0.42) | TDO2ADKCAMKK2CCNE1CDK2 | |
| SCHEMBL5775480 | 0.81 | TDO2 (0.42) | TDO2ADKCAMKK2CCNE1CDK2 | |
| SCHEMBL5776461 | 0.81 | TDO2 (0.42) | TDO2ADKCAMKK2CCNE1CDK2 | |
| SCHEMBL23928381 | 0.79 | FEN1 (0.43) | TDO2FEN1ALOX5AP | |
| SCHEMBL28907422 | 0.76 | NOS3 (0.37) | ADKNOS3NOS1NOS2USP7 | |
| SCHEMBL3388421 | 0.76 | NOS3 (0.37) | ADKFEN1NOS3NOS1NOS2 | |
| SCHEMBL928999 | 0.75 | NOS3 (0.45) | TDO2CAMKK2FEN1NOS3NOS1 | |
| SCHEMBL29526095 | 0.75 | NOS3 (0.45) | TDO2CAMKK2FEN1NOS3NOS1 | |
| SCHEMBL27673013 | 0.75 | ABCB1 (0.42) | ADKCCNE1CDK2CCNT1CDK1 | |
| SCHEMBL28282661 | 0.75 | NOS2 (0.39) | ADKCAMKK2CCNE1CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109415358-A | 6-aminopyridin-3-ylthiazoles as ROR gamma t modulators | 詹森药业有限公司 | 2019-03-01 | — | — | CN | disclosed |