Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 5/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5775480 | 1.00 | TDO2 (0.42) | TDO2NOS3NOS2CAMKK2FEN1 | |
| SCHEMBL5776718 | 1.00 | TDO2 (0.42) | TDO2NOS3NOS2CAMKK2FEN1 | |
| SCHEMBL29526095 | 0.90 | NOS3 (0.45) | TDO2NOS3NOS2CAMKK2FEN1 | |
| SCHEMBL928999 | 0.90 | NOS3 (0.45) | TDO2NOS3NOS2CAMKK2FEN1 | |
| SCHEMBL551586 | 0.84 | SLC18A3 (0.46) | JAK2JAK1HTR2AHTR2CHTR2B | |
| SCHEMBL23928381 | 0.81 | FEN1 (0.43) | TDO2FEN1ALOX5AP | |
| SCHEMBL2244757 | 0.81 | TLR9 (0.43) | NOS3NOS2HTR2C | |
| SCHEMBL30873830 | 0.81 | NOS3 (0.38) | NOS3NOS2 | |
| SCHEMBL30769910 | 0.81 | TLR9 (0.43) | NOS3NOS2HTR2C | |
| SCHEMBL28284231 | 0.81 | TDO2 (0.40) | TDO2NOS3NOS2CAMKK2FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7098220-B2 | Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-08-29 | — | — | US | disclosed |
| EP-1558612-B1 | IMIDAZOPYRIDINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2006-08-23 | — | — | EP | disclosed |
| US-20060069117-A1 | Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-03-30 | — | — | US | disclosed |
| EP-1558612-A1 | IMIDAZOPYRIDINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004043957-A1 | IMIDAZOPYRIDINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2004-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069117-A1 | Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same | PRKAA1, PRKAB1, PRKAB2 | TDO2 4014/4885NOS3 735/4885NOS2 554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.