Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 4/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | GRM5 | P41594 | 3/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2832743 | 0.86 | SORT1 (0.34) | SORT1RIPK1KMT2AGRM5KDM4E | |
| SCHEMBL2826030 | 0.82 | PIK3CA (0.37) | SMN1; SMN2SORT1RIPK1KDM4EHTT | |
| SCHEMBL2829067 | 0.80 | CTSK (0.35) | SORT1RIPK1MEN1KMT2AGRM5 | |
| SCHEMBL2826649 | 0.80 | HTR2C (0.36) | SMN1; SMN2SORT1RIPK1GRM5PIK3C3 | |
| SCHEMBL2830051 | 0.79 | RAB9A (0.40) | SMN1; SMN2MEN1KMT2AGRM5HTT | |
| SCHEMBL2828980 | 0.79 | SORT1 (0.41) | SMN1; SMN2SORT1PIK3C3 | |
| SCHEMBL2829325 | 0.79 | JAK2 (0.41) | SORT1MEN1KMT2APIK3C3 | |
| SCHEMBL2833176 | 0.79 | SORT1 (0.41) | SORT1GRM5PIK3C3 | |
| SCHEMBL2829035 | 0.79 | AURKB (0.37) | GRM5 | |
| SCHEMBL2830257 | 0.78 | GRM5 (0.50) | SORT1KMT2AGRM5HTTPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |