Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 9/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | DDX3X | O00571 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827687 | 0.87 | MEN1 (0.49) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2830058 | 0.87 | LMNA (0.50) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL2829161 | 0.83 | HPGD (0.50) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2826420 | 0.83 | LMNA (0.47) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL2829476 | 0.82 | AKR1C3 (0.48) | MAPTMEN1KMT2ASMN1; SMN2XBP1 | |
| SCHEMBL2829084 | 0.81 | HPGD (0.48) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2829497 | 0.80 | LMNA (0.49) | MAPTMEN1KMT2ASMN1; SMN2XBP1 | |
| SCHEMBL2826660 | 0.80 | LMNA (0.46) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2830110 | 0.79 | RAB9A (0.46) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL2828556 | 0.78 | MAOB (0.46) | MAPTGAAMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |