Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | ESRRB | O95718 | 1/20 | 0.33 |
| ▸ | ESRRA | P11474 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650747 | 0.76 | KDM4E (0.36) | ALDH1A1LMNAGAASMN1; SMN2TSHR | |
| SCHEMBL11313945 | 0.76 | LMNA (0.35) | GPR84ALDH1A1LMNAGAAAPLNR | |
| SCHEMBL8492592 | 0.76 | POLB (0.37) | GABRA1GABRB2GPR84LMNAPOLB | |
| SCHEMBL8752102 | 0.73 | ALDH1A1 (0.31) | ALDH1A1LMNA | |
| SCHEMBL10485433 | 0.73 | NOS3 (0.31) | GPR84ALDH1A1NOS3NOS2ESR1 | |
| SCHEMBL10870742 | 0.72 | CA12 (0.41) | GABRA1GABRB2ALOX15ALOX12ALDH1A1 | |
| SCHEMBL4867080 | 0.72 | KDM4E (0.37) | ALOX15ALOX12ALDH1A1LMNAPOLB | |
| SCHEMBL127356 | 0.72 | KDM4E (0.37) | ALOX15ALOX12ALDH1A1LMNAPOLB | |
| SCHEMBL11368853 | 0.72 | GABRA1 (0.46) | GABRA1GABRB2ALOX15ALOX12ALDH1A1 | |
| SCHEMBL29378184 | 0.72 | KDM4E (0.37) | ALOX15ALOX12ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563043-A | SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1 | 葛兰素史密斯克莱知识产权发展有限公司 | 2019-04-02 | — | — | CN | disclosed |