Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | MAPT | P10636 | 2/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | NQO1 | P15559 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6783648 | 0.86 | POLB (0.64) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8006543 | 0.84 | PARP10 (0.58) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL10927106 | 0.83 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL3279381 | 0.81 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| Ether SCHEMBL28296537 | 0.81 | ALDH1A1 (0.60) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL14756119 | 0.81 | SMN1; SMN2 (0.77) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8968174 | 0.80 | SMN1; SMN2 (0.60) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL28573186 | 0.80 | SMN1; SMN2 (0.60) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8968222 | 0.80 | SMN1; SMN2 (0.60) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL14341655 | 0.79 | SMN1; SMN2 (0.61) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180194732-A1 | MULTI-API LOADING PRODRUGS | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2018-07-12 | — | — | US | disclosed |
| US-20160024011-A1 | Multi-API Loading Prodrugs | ALKERMES PHARMA IRELAND LTD (IE) | 2016-01-28 | — | — | US | disclosed |
| US-20140243286-A1 | BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME | COFERON, INC. (US) | 2014-08-28 | — | — | US | disclosed |
| US-20140243322-A1 | BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME | COFERON, INC. (US) | 2014-08-28 | — | — | US | disclosed |
| EP-2014643-B1 | PARA-METHOXYANILINE DERIVATIVES INCREASING THE ANTIKNOCK RATING OF HYDROCARBON FUELS AND COMPOSITIONS BASED THEREON | ZAO IFOKHIM (RU) | 2013-11-20 | — | — | EP | disclosed |
| US-20120202823-A1 | Multi-API Loading Prodrugs | ALKERMES, INC. | 2012-08-09 | — | — | US | disclosed |
| EP-2014643-A1 | PARA-ETHOXYANILINE DERIVATIVES INCREASING THE ANTIKNOCK RATING OF HYDROCARBON FUELS AND COMPOSITIONS BASED THEREON | Obshestvo S Ogranichennoy Otvetstvennostiu Inoxim (RU) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007105982-A1 | PARA-ETHOXYANILINE DERIVATIVES ENHANCING THE ANTIKNOCK RATING OF HYDROCARBON FUELS AND COMPOSITIONS BASED THEREON | OBSHESTVO S OGRANICHENNOY OTVETSTVENNJCTY 'INOXIM' (RU) | 2007-09-20 | — | — | WO | disclosed |
| US-6710060-B2 | 4-hydroxypiperidine derivatives having antiarrhythmic activity | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2004-03-23 | — | — | US | disclosed |
| US-6642257-B2 | Fewer side-effects than do the conventional analgesics; 4-hydroxypiperidine derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2003-11-04 | — | — | US | disclosed |
| US-20020188006-A1 | 4-hydroxypiperidine derivatives having antiarrhythmic activity | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-12 | — | — | US | disclosed |
| US-20020049229-A1 | Agents for treating neuropathic pain | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-25 | — | — | US | disclosed |
| EP-1182193-A1 | REMEDIES FOR NEUROPATHIC PAIN | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-27 | — | — | EP | disclosed |
| EP-1182192-A1 | 4-HYDROXYPIPERIDINE DERIVATIVES HAVING ANTIARRHYTHMIC EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243322-A1 | BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME | BRDT, BRD2, BRD4 | ALDH1A1 4558/4885LMNA 3780/4885MAPT 2520/4885 |
| US-20160024011-A1 | Multi-API Loading Prodrugs | AADAC, PAICS, ABCG2 | ALDH1A1 525/4885LMNA 2855/4885MAPT 4018/4885 |
| US-20140243286-A1 | BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME | BRDT, BRD4, BRD1 | ALDH1A1 4589/4885LMNA 1148/4885MAPT 1845/4885 |
| US-20020049229-A1 | Agents for treating neuropathic pain | OPRM1, OPRK1, OPRL1 | ALDH1A1 310/4885LMNA 4829/4885MAPT 3368/4885 |
| US-20020188006-A1 | 4-hydroxypiperidine derivatives having antiarrhythmic activity | SCN5A, RYR2, SCN1B | ALDH1A1 416/4885LMNA 337/4885MAPT 4760/4885 |
| US-20120202823-A1 | Multi-API Loading Prodrugs | AADAC, PAICS, ABCG2 | ALDH1A1 525/4885LMNA 2855/4885MAPT 4018/4885 |
| US-20180194732-A1 | MULTI-API LOADING PRODRUGS | AADAC, PAICS, ABCG2 | ALDH1A1 525/4885LMNA 2855/4885MAPT 4018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.