Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 5/20 | 0.39 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ASPH | Q12797 | 2/20 | 0.35 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.35 |
| ▸ | KMO | O15229 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18366042 | 0.80 | ALDH1A1 (0.38) | SIRT6ALDH1A1L3MBTL1TDP1MAPT | |
| SCHEMBL29185911 | 0.74 | KDM4E (0.41) | SIRT6KDM4ENAPRTHCAR2ALDH1A1 | |
| SCHEMBL20929035 | 0.73 | KDM4E (0.40) | SIRT6KDM4ENAPRTHCAR2ALDH1A1 | |
| SCHEMBL18644698 | 0.73 | HCAR2 (0.41) | SIRT6KDM4ENAPRTHCAR2ALDH1A1 | |
| SCHEMBL70035 | 0.72 | KDM4E (0.59) | SIRT6KDM4ENAPRTHCAR2ALDH1A1 | |
| SCHEMBL19875368 | 0.71 | CYP1A2 (0.47) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL287121 | 0.70 | SIRT6 (0.72) | SIRT6KDM4ENAPRTHCAR2ALDH1A1 | |
| SCHEMBL11265141 | 0.70 | ALOX15 (0.50) | SIRT6KDM4ENAPRTHCAR2ALDH1A1 | |
| SCHEMBL30159768 | 0.70 | SIRT6 (0.72) | SIRT6KDM4ENAPRTHCAR2ALDH1A1 | |
| SCHEMBL30241953 | 0.70 | MEN1 (0.49) | KDM4ENAPRTHCAR2ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641875-A | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS | 辉瑞公司 | 2019-04-16 | — | — | CN | disclosed |